Products 929095-18-1
CAS 929095-18-1 appears in our catalog under these names: GSK 461364, >95% (HPLC), GSK461364, GSK461364/ 99%, GSK 461364, GSK461364 98+%. Offered by: TRC, GLPBio, TargetMol, Biosynth, Ambeed. Available pack sizes: 2,5mg, 5mg, 10mg, 10mM (in 1ml dmso), 50mg, 500mg, 1mg, 2mg.
GSK461364 is a member of the class of benzimidazoles that is 1H-benzimidazole substituted by 5-carbamoyl-4-{(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy}thiophen-2-yl and (4-methylpiperazin-1-yl)methyl groups at positions 1 and 6, respectively. It is an ATP-competitive polo-like kinase 1 (PLK1) inhibitor (Ki = 2.2 nM). It has a role as an EC 2.7.11.21 (polo kinase) inhibitor, an antineoplastic agent and an apoptosis inducer. It is a primary carboxamide, a member of benzimidazoles, an ether, a member of thiophenes, a N-methylpiperazine and a member of (trifluoromethyl)benzenes.
Source: ChEBI
| Molecular formula | C27H28F3N5O2S |
|---|---|
| Molecular weight | 543.6 g/mol |
| IUPAC name | 5-[6-[(4-methylpiperazin-1-yl)methyl]benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamide |
| InChIKey | ZHJGWYRLJUCMRT-QGZVFWFLSA-N |
| SMILES | C[C@H](C1=CC=CC=C1C(F)(F)F)OC2=C(SC(=C2)N3C=NC4=C3C=C(C=C4)CN5CCN(CC5)C)C(=O)N |
Computed by PubChem (NCBI)