(R)-N4-(3-Chloro-4-(thiazol-2-ylmethoxy)phenyl)-N6-(4-methyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine, 99%
cas: 845272-21-1 — see every product listed under this CAS number, including other names
(R)-N4-(3-Chloro-4-(thiazol-2-ylmethoxy)phenyl)-N6-(4-methyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine, 99% (CAS 845272-21-1) is a chemical reagent available from Chemat. Available pack sizes: 2mg, 5mg, 10mg, 25mg, 50mg, 100mg, 250mg. Offered by: Chemat, BLDpharm.
| brand | Chemat |
|---|---|
| catalog number | Ch11G4QD-2mg |
| cas | 845272-21-1 |
| size | 2mg |
| availability | 0.1g |
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Available pack sizes
| brand | size | price | |
|---|---|---|---|
| Chemat | 2mg | 338.00 Pln | |
| Chemat | 5mg | 376.40 Pln | |
| Chemat | 10mg | 573.20 Pln | |
| Chemat | 25mg | 918.80 Pln | |
| Chemat | 50mg | 1446.80 Pln | |
| BLDpharm | 2mg | 469.86 Pln | |
| BLDpharm | 5mg | 569.82 Pln | |
| BLDpharm | 10mg | 869.72 Pln | |
| BLDpharm | 25mg | 1708.31 Pln | |
| BLDpharm | 50mg | 2035.97 Pln | |
| BLDpharm | 100mg | 3346.62 Pln | |
| BLDpharm | 250mg | 8250.45 Pln |
properties
| purity | 99% |
|---|---|
| delivery time | 3 weeks |
Varlitinib is a member of the class of quinazolines that is quinazoline substituted by {3-chloro-4-[(1,3-thiazol-2-yl)methoxy]phenyl}amino and [(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]amino groups at positions 4 and 6, respectively. It is a tyrosine kinase inhibitor of both ErbB-2 (Her-2/neu) and EGFR and has shown significant anti-tumour activity in preclinical models of human breast, lung, and epidermal carcinoma tumours. It has a role as an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor, an apoptosis inducer and an epidermal growth factor receptor antagonist. It is an aromatic ether, a quinazoline, an oxazoline, a member of 1,3-thiazoles, a substituted aniline, a secondary amino compound and a member of monochlorobenzenes.
Source: ChEBI
| Molecular formula | C22H19ClN6O2S |
|---|---|
| Molecular weight | 466.9 g/mol |
| IUPAC name | 4-N-[3-chloro-4-(1,3-thiazol-2-ylmethoxy)phenyl]-6-N-[(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]quinazoline-4,6-diamine |
| InChIKey | UWXSAYUXVSFDBQ-CYBMUJFWSA-N |
| SMILES | C[C@@H]1COC(=N1)NC2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=NC=CS5)Cl |
Computed by PubChem (NCBI)