Varlitinib

cas: 845272-21-1 — see every product listed under this CAS number, including other names

Varlitinib (CAS 845272-21-1) is a chemical reagent available from Chemat. Available pack sizes: 500mg, 10mg, 5mg, 25mg, 100mg, 50mg. Offered by: TRC, Biosynth.

brandTRC
catalog numberTRC-V099100-500MG
cas845272-21-1
size500mg
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Available pack sizes

brand size price
TRC 500mg price on request
Biosynth 10mg price on request
Biosynth 5mg price on request
Biosynth 25mg price on request
Biosynth 100mg price on request
Biosynth 50mg price on request

properties

purityNo data
delivery timeTo be confirmed by Chemat
Structural formula: {0} (CAS {1})

Varlitinib is a member of the class of quinazolines that is quinazoline substituted by {3-chloro-4-[(1,3-thiazol-2-yl)methoxy]phenyl}amino and [(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]amino groups at positions 4 and 6, respectively. It is a tyrosine kinase inhibitor of both ErbB-2 (Her-2/neu) and EGFR and has shown significant anti-tumour activity in preclinical models of human breast, lung, and epidermal carcinoma tumours. It has a role as an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor, an apoptosis inducer and an epidermal growth factor receptor antagonist. It is an aromatic ether, a quinazoline, an oxazoline, a member of 1,3-thiazoles, a substituted aniline, a secondary amino compound and a member of monochlorobenzenes.

Source: ChEBI

Identity
Molecular formulaC22H19ClN6O2S
Molecular weight466.9 g/mol
IUPAC name4-N-[3-chloro-4-(1,3-thiazol-2-ylmethoxy)phenyl]-6-N-[(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]quinazoline-4,6-diamine
InChIKeyUWXSAYUXVSFDBQ-CYBMUJFWSA-N
SMILESC[C@@H]1COC(=N1)NC2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=NC=CS5)Cl

Computed by PubChem (NCBI)

Synonyms: VARLITINIB, varlitinibum, Varlitinib [USAN:INN], Varlitinib [USAN], C22H19ClN6O2S, Varlitinib free base, VARLITINIB [INN], Varlitinib (USAN/INN), VARLITINIB [WHO-DD], orb1685624
Isomers (same molecular formula)
4-[4-[7-amino-2-(1,2,3-benzothiadiazol-7-yl)-3-chlorofuro[2,3-c]pyridin-4-yl]pyrazol-1-yl]cyclohexan-1-ol C22H19ClN6O2S

Also listed as

Varlitinib/ 99.7% (existing batch purity) TargetMol CAS 845272-21-1
Varlitinib, 99.92% MedChemExpress CAS 845272-21-1
Varlitinib, 99% Ambeed CAS 845272-21-1
(R)-N4-(3-Chloro-4-(thiazol-2-ylmethoxy)phenyl)-N6-(4-methyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine, 99% Chemat CAS 845272-21-1