Products 845272-21-1
CAS 845272-21-1 appears in our catalog under these names: Varlitinib, Varlitinib/ 99.7% (existing batch purity), Varlitinib, 99.92%, Varlitinib, 99%, (R)-N4-(3-Chloro-4-(thiazol-2-ylmethoxy)phenyl)-N6-(4-methyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine, 99%. Offered by: TRC, TargetMol, Biosynth, MedChemExpress, Ambeed. Available pack sizes: 500mg, 2mg, 5mg, 10mg, 25mg, 100mg, 50mg, 10 mg.
Varlitinib is a member of the class of quinazolines that is quinazoline substituted by {3-chloro-4-[(1,3-thiazol-2-yl)methoxy]phenyl}amino and [(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]amino groups at positions 4 and 6, respectively. It is a tyrosine kinase inhibitor of both ErbB-2 (Her-2/neu) and EGFR and has shown significant anti-tumour activity in preclinical models of human breast, lung, and epidermal carcinoma tumours. It has a role as an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor, an apoptosis inducer and an epidermal growth factor receptor antagonist. It is an aromatic ether, a quinazoline, an oxazoline, a member of 1,3-thiazoles, a substituted aniline, a secondary amino compound and a member of monochlorobenzenes.
Source: ChEBI
| Molecular formula | C22H19ClN6O2S |
|---|---|
| Molecular weight | 466.9 g/mol |
| IUPAC name | 4-N-[3-chloro-4-(1,3-thiazol-2-ylmethoxy)phenyl]-6-N-[(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]quinazoline-4,6-diamine |
| InChIKey | UWXSAYUXVSFDBQ-CYBMUJFWSA-N |
| SMILES | C[C@@H]1COC(=N1)NC2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=NC=CS5)Cl |
Computed by PubChem (NCBI)