6-Fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid

cas: 96187-53-0 — see every product listed under this CAS number, including other names

6-Fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid (CAS 96187-53-0) is a chemical reagent available from Chemat. Available pack sizes: 100mg, 250mg, 500mg, 2000mg, 1000mg. Offered by: Biosynth.

brandBiosynth
catalog numberFF44184-100mg
cas96187-53-0
size100mg
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properties

categoryResearch Chemicals
purityNo data
delivery time1-2 weeks
Structural formula: {0} (CAS {1})

Brequinar is a quinolinemonocarboxylic acid that is quinoline substituted by 2'-fluoro[1,1'-biphenyl]-4-yl, methyl, carboxy and fluoro groups at positions 2, 3, 4, and 6, respectively. It is an inhibitor of dihydroorotate dehydrogenase, an enzyme that is required for de novo pyrimidine biosynthesis. The compound exhibits antineoplastic and antiviral properties. It has a role as an anticoronaviral agent, an antiviral agent, an antimetabolite, an antineoplastic agent, an immunosuppressive agent, a pyrimidine synthesis inhibitor and an EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor. It is a member of biphenyls, a monocarboxylic acid, a quinolinemonocarboxylic acid and a member of monofluorobenzenes. It is a conjugate acid of a brequinar(1-).

Source: ChEBI

Identity
Molecular formulaC23H15F2NO2
Molecular weight375.4 g/mol
IUPAC name6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid
InChIKeyPHEZJEYUWHETKO-UHFFFAOYSA-N
SMILESCC1=C(C2=C(C=CC(=C2)F)N=C1C3=CC=C(C=C3)C4=CC=CC=C4F)C(=O)O

Computed by PubChem (NCBI)

Synonyms: Brequinar, brequinarum, 6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid, 4-Quinolinecarboxylic acid, 6-fluoro-2-(2'-fluoro(1,1'-biphenyl)-4-yl)-3-methyl-, 4-Quinolinecarboxylic acid, 6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-, 6-fluoro-2-(4-(2-fluorophenyl)phenyl)-3-methylquinoline-4-carboxylic acid, 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinolinecarboxylic acid, 6-Fluoro-2-(2'-fluoro(1,1'-biphenyl)-4-yl)-3-methyl-4-quinolinecarboxylic Acid, Bipenquinate, 6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid

Also listed as

6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid, 95% Combi-blocks CAS 96187-53-0
Brequinar/ 99.21% (existing batch purity) TargetMol CAS 96187-53-0
Brequinar GLPBio CAS 96187-53-0
Brequinar, >98.0%(HPLC) TCI CAS 96187-53-0
Brequinar, 99.89% MedChemExpress CAS 96187-53-0
Brequinar (Standard) MedChemExpress CAS 96187-53-0
6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid, 98% Fluorochem CAS 96187-53-0
Brequinar, 96% Ambeed CAS 96187-53-0
6-Fluoro-2-(2'-fluoro-[1，1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid, 98% Chemat CAS 96187-53-0