Products 96187-53-0

CAS 96187-53-0 appears in our catalog under these names: 6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid, 95%, Brequinar/ 99.21% (existing batch purity), Brequinar, Brequinar, >98.0%(HPLC), 6-Fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid. Offered by: Combi-blocks, TargetMol, GLPBio, TCI, Biosynth. Available pack sizes: 250mg, 1g, 100mg, 2mg, 5mg, 10mg, 25mg, 50mg.

6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid, 95%
Combi-blocks
  • size: 250mg, 1g, 100mg
  • Variants: 3
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Brequinar/ 99.21% (existing batch purity)
TargetMol
  • size: 2mg, 5mg, 10mg, 25mg
  • Variants: 6
from 452.11
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Brequinar
GLPBio
  • size: 10mg, 5mg
  • Variants: 2
from 583.00
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Brequinar, >98.0%(HPLC)
TCI
  • size: 20mg, 100mg
  • Variants: 2
from 393.71
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6-Fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid
Biosynth
  • size: 100mg, 250mg, 500mg, 2000mg
  • Variants: 5
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Brequinar 96%
Ambeed
  • size: 50mg, 100mg, 250mg, 1g
  • Variants: 4
from 921.06
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6-Fluoro-2-(2'-fluoro-[1，1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid, 98%, 98%
Chemat
  • size: 100mg, 250mg, 1g
  • Variants: 3
from 568.40
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Brequinar, 99.89%
MedChemExpress
  • size: 10mM/1mL, 100 mg, 25 mg, 5 mg
  • Variants: 6
from 524.03
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Brequinar (Standard)
MedChemExpress
  • size: 25 mg, 10 mg, 100 mg, 5 mg
  • Variants: 5
from 1081.31
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6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid, 98%
Fluorochem
  • size: 100mg, 250mg, 1g
  • Variants: 3
from 945.52
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Structural formula: {0} (CAS {1})

Brequinar is a quinolinemonocarboxylic acid that is quinoline substituted by 2'-fluoro[1,1'-biphenyl]-4-yl, methyl, carboxy and fluoro groups at positions 2, 3, 4, and 6, respectively. It is an inhibitor of dihydroorotate dehydrogenase, an enzyme that is required for de novo pyrimidine biosynthesis. The compound exhibits antineoplastic and antiviral properties. It has a role as an anticoronaviral agent, an antiviral agent, an antimetabolite, an antineoplastic agent, an immunosuppressive agent, a pyrimidine synthesis inhibitor and an EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor. It is a member of biphenyls, a monocarboxylic acid, a quinolinemonocarboxylic acid and a member of monofluorobenzenes. It is a conjugate acid of a brequinar(1-).

Source: ChEBI

Identity
Molecular formulaC23H15F2NO2
Molecular weight375.4 g/mol
IUPAC name6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid
InChIKeyPHEZJEYUWHETKO-UHFFFAOYSA-N
SMILESCC1=C(C2=C(C=CC(=C2)F)N=C1C3=CC=C(C=C3)C4=CC=CC=C4F)C(=O)O

Computed by PubChem (NCBI)

Synonyms: Brequinar, brequinarum, 6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid, 4-Quinolinecarboxylic acid, 6-fluoro-2-(2'-fluoro(1,1'-biphenyl)-4-yl)-3-methyl-, 4-Quinolinecarboxylic acid, 6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-, 6-fluoro-2-(4-(2-fluorophenyl)phenyl)-3-methylquinoline-4-carboxylic acid, 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinolinecarboxylic acid, 6-Fluoro-2-(2'-fluoro(1,1'-biphenyl)-4-yl)-3-methyl-4-quinolinecarboxylic Acid, Bipenquinate, 6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid