Brequinar

cas: 96187-53-0 — see every product listed under this CAS number, including other names

Brequinar (CAS 96187-53-0) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 5mg. Offered by: GLPBio.

brandGLPBio
catalog numberGC19082-10
cas96187-53-0
size10mg
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Available pack sizes

brand size price
GLPBio 10mg 700.01 Pln
GLPBio 5mg 583.00 Pln

properties

purityNo data
delivery timeTo be confirmed by Chemat
Structural formula: {0} (CAS {1})

Brequinar is a quinolinemonocarboxylic acid that is quinoline substituted by 2'-fluoro[1,1'-biphenyl]-4-yl, methyl, carboxy and fluoro groups at positions 2, 3, 4, and 6, respectively. It is an inhibitor of dihydroorotate dehydrogenase, an enzyme that is required for de novo pyrimidine biosynthesis. The compound exhibits antineoplastic and antiviral properties. It has a role as an anticoronaviral agent, an antiviral agent, an antimetabolite, an antineoplastic agent, an immunosuppressive agent, a pyrimidine synthesis inhibitor and an EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor. It is a member of biphenyls, a monocarboxylic acid, a quinolinemonocarboxylic acid and a member of monofluorobenzenes. It is a conjugate acid of a brequinar(1-).

Source: ChEBI

Identity
Molecular formulaC23H15F2NO2
Molecular weight375.4 g/mol
IUPAC name6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid
InChIKeyPHEZJEYUWHETKO-UHFFFAOYSA-N
SMILESCC1=C(C2=C(C=CC(=C2)F)N=C1C3=CC=C(C=C3)C4=CC=CC=C4F)C(=O)O

Computed by PubChem (NCBI)

Synonyms: Brequinar, brequinarum, 6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid, 4-Quinolinecarboxylic acid, 6-fluoro-2-(2'-fluoro(1,1'-biphenyl)-4-yl)-3-methyl-, 4-Quinolinecarboxylic acid, 6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-, 6-fluoro-2-(4-(2-fluorophenyl)phenyl)-3-methylquinoline-4-carboxylic acid, 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methyl-4-quinolinecarboxylic acid, 6-Fluoro-2-(2'-fluoro(1,1'-biphenyl)-4-yl)-3-methyl-4-quinolinecarboxylic Acid, Bipenquinate, 6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid

Also listed as

6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid, 95% Combi-blocks CAS 96187-53-0
Brequinar/ 99.21% (existing batch purity) TargetMol CAS 96187-53-0
Brequinar, >98.0%(HPLC) TCI CAS 96187-53-0
6-Fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid Biosynth CAS 96187-53-0
Brequinar 96% Ambeed CAS 96187-53-0
6-Fluoro-2-(2'-fluoro-[1，1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid, 98%, 98% Chemat CAS 96187-53-0
Brequinar, 99.89% MedChemExpress CAS 96187-53-0
Brequinar (Standard) MedChemExpress CAS 96187-53-0
6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid, 98% Fluorochem CAS 96187-53-0