ABT–263 (Navitoclax)

cas: 923564-51-6 — see every product listed under this CAS number, including other names

ABT–263 (Navitoclax) (CAS 923564-51-6) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 100mg, 5mg, 10mM (in 1ml dmso), 50mg. Offered by: GLPBio.

brandGLPBio
catalog numberGC12405-10
cas923564-51-6
size10mg
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Available pack sizes

brand size price
GLPBio 10mg 662.57 Pln
GLPBio 100mg 1565.90 Pln
GLPBio 5mg 597.04 Pln
GLPBio 10mM (in 1ml dmso) 760.86 Pln
GLPBio 50mg 1121.26 Pln

properties

purityNo data
delivery timeTo be confirmed by Chemat

Navitoclax is a N-sulfonylcarboxamide resulting from the formal condensation of the carboxy group of 4-{4-[(4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro[biphenyl]-2-yl)methyl]piperazin-1-yl}benzoic acid with the amino group of 4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-[(trifluoromethyl)sulfonyl]benzenesulfonamide. It is a BH3-mimetic drug which targets the anti-apoptotic B-cell lymphoma-2 (BCL-2) family proteins, including BCL-2, BCL-xL, and BCL-w, and induces apoptosis in cancer cells. Currently under clinical investigation as treatment for solid tumors and hematologic malignancies. It has a role as a B-cell lymphoma 2 inhibitor, an antineoplastic agent and an apoptosis inducer. It is a member of piperazines, an aryl sulfide, a sulfone, an organofluorine compound, a member of morpholines, a secondary amino compound, a tertiary amino compound, a member of monochlorobenzenes and a N-sulfonylcarboxamide.

Source: ChEBI

Identity
Molecular formulaC47H55ClF3N5O6S3
Molecular weight974.6 g/mol
IUPAC name4-[4-[[2-(4-chlorophenyl)-5,5-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide
InChIKeyJLYAXFNOILIKPP-KXQOOQHDSA-N
SMILESCC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)N[C@H](CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C

Computed by PubChem (NCBI)

Synonyms: Navitoclax, navitoclaxum, BcI-2 Family Protein Inhibitor ABT-263, Navitoclax (ABT-263), C47H55ClF3N5O6S3, Navitoclax [USAN], Navitoclax [USAN:INN], NAVITOCLAX [MI], Navitoclax; ABT-263, NAVITOCLAX [INN]
Related forms of this compound
4-[4-[[2-(4-chlorophenyl)-5,5-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-(2,2,3,3,5,5,6,6-octadeuteriomorpholin-4-yl)-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide C47H55ClF3N5O6S3

Also listed as

ABT 263, >95% (HPLC) TRC CAS 923564-51-6
Navitoclax/ 98.88% (existing batch purity) TargetMol CAS 923564-51-6
Navitoclax Biosynth CAS 923564-51-6
4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide, 98%, 98% Chemat CAS 923564-51-6
Navitoclax, 99.97% MedChemExpress CAS 923564-51-6
Navitoclax (Standard), 99.14% MedChemExpress CAS 923564-51-6
Navitoclax, min. 95 %, 50 mg Roth CAS 923564-51-6
Navitoclax, min. 95 %, 100 mg Roth CAS 923564-51-6
Navitoclax, min. 95 %, 250 mg Roth CAS 923564-51-6
Navitoclax, min. 95 %, 500 mg Roth CAS 923564-51-6