Products 923564-51-6

CAS 923564-51-6 appears in our catalog under these names: ABT 263, >95% (HPLC), Navitoclax/ 98.88% (existing batch purity), ABT–263 (Navitoclax), Navitoclax, 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide, 98%, 98%. Offered by: TRC, TargetMol, GLPBio, Biosynth, Chemat. Available pack sizes: 10mg, 250mg, 5mg, 25mg, 50mg, 100mg, 200mg, 500mg.

ABT 263, >95% (HPLC)
TRC
  • size: 10mg, 250mg, 5mg
  • Variants: 3
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Navitoclax/ 98.88% (existing batch purity)
TargetMol
  • size: 5mg, 10mg, 25mg, 50mg
  • Variants: 7
from 452.11
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ABT–263 (Navitoclax)
GLPBio
  • size: 10mg, 100mg, 5mg, 10mM (in 1ml dmso)
  • Variants: 5
from 597.04
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Navitoclax
Biosynth
  • size: 50mg, 2mg, 100mg, 1mg
  • Variants: 9
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4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide, 98%, 98%
Chemat
  • size: 1mg, 5mg, 10mg, 25mg
  • Variants: 8
from 146.00
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Navitoclax, 99.97%
MedChemExpress
  • size: 100 mg, 500 mg, 50 mg, 10mM/1mL
  • Variants: 8
from 361.49
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Navitoclax (Standard), 99.14%
MedChemExpress
  • size: 100 mg, 10 mg, 50 mg, 25 mg
  • Variants: 5
from 598.33
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Navitoclax, min. 95 %, 50 mg
Roth
  • size: 50mg
  • Variants: 1
from 1552.75
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Navitoclax, min. 95 %, 100 mg
Roth
  • size: 100mg
  • Variants: 1
from 2166.30
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Navitoclax, min. 95 %, 250 mg
Roth
  • size: 250mg
  • Variants: 1
from 4290.12
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Navitoclax, min. 95 %, 500 mg
Roth
  • size: 500mg
  • Variants: 1
from 7027.49
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Navitoclax is a N-sulfonylcarboxamide resulting from the formal condensation of the carboxy group of 4-{4-[(4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro[biphenyl]-2-yl)methyl]piperazin-1-yl}benzoic acid with the amino group of 4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-[(trifluoromethyl)sulfonyl]benzenesulfonamide. It is a BH3-mimetic drug which targets the anti-apoptotic B-cell lymphoma-2 (BCL-2) family proteins, including BCL-2, BCL-xL, and BCL-w, and induces apoptosis in cancer cells. Currently under clinical investigation as treatment for solid tumors and hematologic malignancies. It has a role as a B-cell lymphoma 2 inhibitor, an antineoplastic agent and an apoptosis inducer. It is a member of piperazines, an aryl sulfide, a sulfone, an organofluorine compound, a member of morpholines, a secondary amino compound, a tertiary amino compound, a member of monochlorobenzenes and a N-sulfonylcarboxamide.

Source: ChEBI

Identity
Molecular formulaC47H55ClF3N5O6S3
Molecular weight974.6 g/mol
IUPAC name4-[4-[[2-(4-chlorophenyl)-5,5-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide
InChIKeyJLYAXFNOILIKPP-KXQOOQHDSA-N
SMILESCC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)N[C@H](CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C

Computed by PubChem (NCBI)

Synonyms: Navitoclax, navitoclaxum, BcI-2 Family Protein Inhibitor ABT-263, Navitoclax (ABT-263), C47H55ClF3N5O6S3, Navitoclax [USAN], Navitoclax [USAN:INN], NAVITOCLAX [MI], Navitoclax; ABT-263, NAVITOCLAX [INN]
Related forms of this compound
4-[4-[[2-(4-chlorophenyl)-5,5-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-(2,2,3,3,5,5,6,6-octadeuteriomorpholin-4-yl)-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide C47H55ClF3N5O6S3