Navitoclax

cas: 923564-51-6 — see every product listed under this CAS number, including other names

Navitoclax (CAS 923564-51-6) is a chemical reagent available from Chemat. Available pack sizes: 50mg, 2mg, 100mg, 1mg, 250mg, 5mg, 10mg, 500mg. Offered by: Biosynth.

brandBiosynth
catalog numberFN16901-50mg
cas923564-51-6
size50mg
Need more information?

Ask us about this product — we're happy to help.

Available pack sizes

brand size price
Biosynth 50mg price on request
Biosynth 2mg price on request
Biosynth 100mg price on request
Biosynth 1mg price on request
Biosynth 250mg price on request
Biosynth 5mg price on request
Biosynth 10mg price on request
Biosynth 500mg price on request
Biosynth 25mg price on request

properties

categoryLife Sciences
sub-category 1Ligands
sub-category 2Protein Interactions
purityNo data
delivery time1-2 weeks

Navitoclax is a N-sulfonylcarboxamide resulting from the formal condensation of the carboxy group of 4-{4-[(4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro[biphenyl]-2-yl)methyl]piperazin-1-yl}benzoic acid with the amino group of 4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-[(trifluoromethyl)sulfonyl]benzenesulfonamide. It is a BH3-mimetic drug which targets the anti-apoptotic B-cell lymphoma-2 (BCL-2) family proteins, including BCL-2, BCL-xL, and BCL-w, and induces apoptosis in cancer cells. Currently under clinical investigation as treatment for solid tumors and hematologic malignancies. It has a role as a B-cell lymphoma 2 inhibitor, an antineoplastic agent and an apoptosis inducer. It is a member of piperazines, an aryl sulfide, a sulfone, an organofluorine compound, a member of morpholines, a secondary amino compound, a tertiary amino compound, a member of monochlorobenzenes and a N-sulfonylcarboxamide.

Source: ChEBI

Identity
Molecular formulaC47H55ClF3N5O6S3
Molecular weight974.6 g/mol
IUPAC name4-[4-[[2-(4-chlorophenyl)-5,5-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide
InChIKeyJLYAXFNOILIKPP-KXQOOQHDSA-N
SMILESCC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)N[C@H](CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C

Computed by PubChem (NCBI)

Synonyms: Navitoclax, navitoclaxum, BcI-2 Family Protein Inhibitor ABT-263, Navitoclax (ABT-263), C47H55ClF3N5O6S3, Navitoclax [USAN], Navitoclax [USAN:INN], NAVITOCLAX [MI], Navitoclax; ABT-263, NAVITOCLAX [INN]
Related forms of this compound
4-[4-[[2-(4-chlorophenyl)-5,5-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-(2,2,3,3,5,5,6,6-octadeuteriomorpholin-4-yl)-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide C47H55ClF3N5O6S3

Also listed as

ABT 263, >95% (HPLC) TRC CAS 923564-51-6
Navitoclax/ 98.88% (existing batch purity) TargetMol CAS 923564-51-6
ABT–263 (Navitoclax) GLPBio CAS 923564-51-6
4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide, 98%, 98% Chemat CAS 923564-51-6
Navitoclax, 99.97% MedChemExpress CAS 923564-51-6
Navitoclax (Standard), 99.14% MedChemExpress CAS 923564-51-6
Navitoclax, min. 95 %, 50 mg Roth CAS 923564-51-6
Navitoclax, min. 95 %, 100 mg Roth CAS 923564-51-6
Navitoclax, min. 95 %, 250 mg Roth CAS 923564-51-6
Navitoclax, min. 95 %, 500 mg Roth CAS 923564-51-6