cas: 923564-51-6 — see every product listed under this CAS number, including other names
Navitoclax (Standard), 99.14% (CAS 923564-51-6) is a chemical reagent available from Chemat. Available pack sizes: 100 mg, 10 mg, 50 mg, 25 mg, 5 mg. Offered by: MedChemExpress.
| brand | MedChemExpress |
|---|---|
| catalog number | HY-10087R-100 mg |
| cas | 923564-51-6 |
| size | 100 mg |
| availability | Get quote |
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| brand | size | price | |
|---|---|---|---|
| MedChemExpress | 100 mg | 2664.91 Pln | |
| MedChemExpress | 10 mg | 839.82 Pln | |
| MedChemExpress | 50 mg | 1935.80 Pln | |
| MedChemExpress | 25 mg | 1415.68 Pln | |
| MedChemExpress | 5 mg | 598.33 Pln |
| delivery time | over 3 weeks |
|---|---|
| purity | 99.14% |
Navitoclax is a N-sulfonylcarboxamide resulting from the formal condensation of the carboxy group of 4-{4-[(4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro[biphenyl]-2-yl)methyl]piperazin-1-yl}benzoic acid with the amino group of 4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-[(trifluoromethyl)sulfonyl]benzenesulfonamide. It is a BH3-mimetic drug which targets the anti-apoptotic B-cell lymphoma-2 (BCL-2) family proteins, including BCL-2, BCL-xL, and BCL-w, and induces apoptosis in cancer cells. Currently under clinical investigation as treatment for solid tumors and hematologic malignancies. It has a role as a B-cell lymphoma 2 inhibitor, an antineoplastic agent and an apoptosis inducer. It is a member of piperazines, an aryl sulfide, a sulfone, an organofluorine compound, a member of morpholines, a secondary amino compound, a tertiary amino compound, a member of monochlorobenzenes and a N-sulfonylcarboxamide.
Source: ChEBI
| Molecular formula | C47H55ClF3N5O6S3 |
|---|---|
| Molecular weight | 974.6 g/mol |
| IUPAC name | 4-[4-[[2-(4-chlorophenyl)-5,5-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-morpholin-4-yl-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide |
| InChIKey | JLYAXFNOILIKPP-KXQOOQHDSA-N |
| SMILES | CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)N[C@H](CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C |
Computed by PubChem (NCBI)