AMG 925, 99.02%
cas: 1401033-86-0 — see every product listed under this CAS number, including other names
AMG 925, 99.02% (CAS 1401033-86-0) is a chemical reagent available from Chemat. Available pack sizes: 25 mg, 5 mg, 1 mg, 10 mg, 100 mg, 50 mg. Offered by: MedChemExpress.
| brand | MedChemExpress |
|---|---|
| catalog number | HY-15889-25 mg |
| cas | 1401033-86-0 |
| size | 25 mg |
| availability | In stock |
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Available pack sizes
| brand | size | price | |
|---|---|---|---|
| MedChemExpress | 25 mg | 1225.27 Pln | |
| MedChemExpress | 5 mg | 528.67 Pln | |
| MedChemExpress | 1 mg | 310.40 Pln | |
| MedChemExpress | 10 mg | 695.86 Pln | |
| MedChemExpress | 100 mg | 2757.79 Pln | |
| MedChemExpress | 50 mg | 1801.13 Pln |
properties
| delivery time | 2-3 weeks |
|---|---|
| purity | 99.02% |
AMG-925 is an organic heterotricyclic compound that is 9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidine which is substituted by a [6-(hydroxyacetyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl]nitrilo group at position 2 and by a trans-4-methylcyclohexyl group at position 9. It is a FLT3 and CDK4 dual kinase inhibitor that has antineoplastic activity. Currently under clinical investigation in patients with relapsed or refractory acute myeloid leukemia (AML). It has a role as an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor, an apoptosis inducer and an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor. It is a primary alpha-hydroxy ketone, an organic heterotricyclic compound, a secondary amino compound, a tertiary amino compound and a naphthyridine derivative.
Source: ChEBI
| Molecular formula | C26H29N7O2 |
|---|---|
| Molecular weight | 471.6 g/mol |
| IUPAC name | 2-hydroxy-1-[2-[[8-(4-methylcyclohexyl)-4,6,8,11-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaen-5-yl]amino]-7,8-dihydro-5H-1,6-naphthyridin-6-yl]ethanone |
| InChIKey | BBUVDDPUURMFOX-UHFFFAOYSA-N |
| SMILES | CC1CCC(CC1)N2C3=C(C=CN=C3)C4=CN=C(N=C42)NC5=NC6=C(CN(CC6)C(=O)CO)C=C5 |
Computed by PubChem (NCBI)
Synonyms:
orb1300495, s7533