Products 1401033-86-0
CAS 1401033-86-0 appears in our catalog under these names: Amg 925, 95%, AMG 925, 99+%, AMG 925/ 99.42% (existing batch purity), AMG 925, AMG 925. Offered by: Combi-blocks, AmBeed, TargetMol, GLPBio, Biosynth. Available pack sizes: 250mg, 1g, 1mg, 2mg, 5mg, 10mg, 25mg, 50mg.
AMG-925 is an organic heterotricyclic compound that is 9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidine which is substituted by a [6-(hydroxyacetyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl]nitrilo group at position 2 and by a trans-4-methylcyclohexyl group at position 9. It is a FLT3 and CDK4 dual kinase inhibitor that has antineoplastic activity. Currently under clinical investigation in patients with relapsed or refractory acute myeloid leukemia (AML). It has a role as an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor, an apoptosis inducer and an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor. It is a primary alpha-hydroxy ketone, an organic heterotricyclic compound, a secondary amino compound, a tertiary amino compound and a naphthyridine derivative.
Source: ChEBI
| Molecular formula | C26H29N7O2 |
|---|---|
| Molecular weight | 471.6 g/mol |
| IUPAC name | 2-hydroxy-1-[2-[[8-(4-methylcyclohexyl)-4,6,8,11-tetrazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaen-5-yl]amino]-7,8-dihydro-5H-1,6-naphthyridin-6-yl]ethanone |
| InChIKey | BBUVDDPUURMFOX-UHFFFAOYSA-N |
| SMILES | CC1CCC(CC1)N2C3=C(C=CN=C3)C4=CN=C(N=C42)NC5=NC6=C(CN(CC6)C(=O)CO)C=C5 |
Computed by PubChem (NCBI)
Synonyms:
orb1300495, s7533