BMS 214662

cas: 195987-41-8 — see every product listed under this CAS number, including other names

BMS 214662 (CAS 195987-41-8) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 5mg, 25mg, 50mg. Offered by: Biosynth.

brandBiosynth
catalog numberVHA98741-10mg
cas195987-41-8
size10mg
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Available pack sizes

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properties

categoryLife Sciences
sub-category 1Ligands
purityNo data
delivery time3-4 Weeks
Structural formula: {0} (CAS {1})

BMS-214662 is a member of the class of benzodiazepines that is 2,3,4,5-tetrahydro-1H-1,4-benzodiazepine substituted by (1H-imidazol-5-yl)methyl, benzyl, (thiophen-2-yl)sulfonyl, and cyano groups at positions 1, 3R, 4 and 7, respectively. It is a potent inhibitor of farnesyltransferase (IC50 = 1.35nM) which was under clinical development for the treatment of solid tumors. It has a role as an antineoplastic agent, an EC 2.5.1.58 (protein farnesyltransferase) inhibitor and an apoptosis inducer. It is a nitrile, a member of benzenes, a benzodiazepine, a member of imidazoles, a member of thiophenes and a sulfonamide.

Source: ChEBI

Identity
Molecular formulaC25H23N5O2S2
Molecular weight489.6 g/mol
IUPAC name(3R)-3-benzyl-1-(1H-imidazol-5-ylmethyl)-4-thiophen-2-ylsulfonyl-3,5-dihydro-2H-1,4-benzodiazepine-7-carbonitrile
InChIKeyOLCWFLWEHWLBTO-HSZRJFAPSA-N
SMILESC1[C@H](N(CC2=C(N1CC3=CN=CN3)C=CC(=C2)C#N)S(=O)(=O)C4=CC=CS4)CC5=CC=CC=C5

Computed by PubChem (NCBI)

Synonyms: BMV, OLCWFLWEHWLBTO-HSZRJFAPSA-N, orb1710238

Also listed as

BMS 214662, >95% (HPLC) TRC CAS 195987-41-8
BMS-214662, 98% AmBeed CAS 195987-41-8
BMS–214662 GLPBio CAS 195987-41-8
BMS-214662 Chemat CAS 195987-41-8
BMS-214662, 99.86% MedChemExpress CAS 195987-41-8