Products 195987-41-8

CAS 195987-41-8 appears in our catalog under these names: BMS 214662, >95% (HPLC), BMS-214662, 98%, BMS–214662, BMS 214662, BMS-214662. Offered by: TRC, AmBeed, GLPBio, Biosynth, Chemat. Available pack sizes: 1mg, 100mg, 10mg, 10mM (in 1ml dmso), 25mg, 5mg, 50mg, 2mg.

BMS 214662, >95% (HPLC)
TRC
  • size: 1mg
  • Variants: 1
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BMS-214662, 98%
AmBeed
  • size: 100mg
  • Variants: 1
from 76067.74
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BMS–214662
GLPBio
  • size: 1mg, 10mg, 100mg, 10mM (in 1ml dmso)
  • Variants: 7
from 1060.41
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BMS 214662
Biosynth
  • size: 10mg, 5mg, 25mg, 50mg
  • Variants: 4
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BMS-214662
Chemat
  • size: 10mg, 2mg
  • Variants: 2
from 1499.60
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BMS-214662, 99.86%
MedChemExpress
  • size: 50 mg, 25 mg, 5 mg, 10mM/1mL
  • Variants: 7
from 1072.02
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Structural formula: {0} (CAS {1})

BMS-214662 is a member of the class of benzodiazepines that is 2,3,4,5-tetrahydro-1H-1,4-benzodiazepine substituted by (1H-imidazol-5-yl)methyl, benzyl, (thiophen-2-yl)sulfonyl, and cyano groups at positions 1, 3R, 4 and 7, respectively. It is a potent inhibitor of farnesyltransferase (IC50 = 1.35nM) which was under clinical development for the treatment of solid tumors. It has a role as an antineoplastic agent, an EC 2.5.1.58 (protein farnesyltransferase) inhibitor and an apoptosis inducer. It is a nitrile, a member of benzenes, a benzodiazepine, a member of imidazoles, a member of thiophenes and a sulfonamide.

Source: ChEBI

Identity
Molecular formulaC25H23N5O2S2
Molecular weight489.6 g/mol
IUPAC name(3R)-3-benzyl-1-(1H-imidazol-5-ylmethyl)-4-thiophen-2-ylsulfonyl-3,5-dihydro-2H-1,4-benzodiazepine-7-carbonitrile
InChIKeyOLCWFLWEHWLBTO-HSZRJFAPSA-N
SMILESC1[C@H](N(CC2=C(N1CC3=CN=CN3)C=CC(=C2)C#N)S(=O)(=O)C4=CC=CS4)CC5=CC=CC=C5

Computed by PubChem (NCBI)

Synonyms: BMV, OLCWFLWEHWLBTO-HSZRJFAPSA-N, orb1710238