Formestane

cas: 566-48-3 — see every product listed under this CAS number, including other names

Formestane (CAS 566-48-3) is a chemical reagent available from Chemat. Available pack sizes: on request, 250mg, 50mg, 2g, 5g, 10g, 25g, 50g. Offered by: Chemat Brand, Mikromol, GLPBio, Biosynth.

brandChemat Brand
catalog numberULF161
cas566-48-3
sizeon request
availability Do potwierdzenia przez Chemat|To be confirmed by Chemat
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Available pack sizes

brand size price
Chemat Brand on request price on request
Mikromol 250mg price on request
GLPBio 50mg 629.80 Pln
Biosynth 2g price on request
Biosynth 5g price on request
Biosynth 10g price on request
Biosynth 25g price on request
Biosynth 50g price on request
Sigma-Aldrich 1G 1070.00 Pln

properties

purityNo data
categoryChemicals
delivery timeTo be confirmed by Chemat
Structural formula: {0} (CAS {1})

Formestane is a 17-oxo steroid that is androst-4-ene-3,17-dione in which the hydrogen at position 4 is replaced by a hydroxy group. Formestane was the first selective, type I steroidal aromatase inhibitor, suppressing oestrogen production from anabolic steroids or prohormones. It was formerly used in the treatment of oestrogen-receptor positive breast cancer in post-meopausal women. As it has poor oral bioavailability, it had to be administered by (fortnightly) intramuscular injection. It fell out of use with the subsequent development of cheaper, orally active aromatase inhibitors. Formestane is listed by the World Anti-Doping Agency as a substance prohibited from use by athletes. It has a role as an antineoplastic agent and an EC 1.14.14.14 (aromatase) inhibitor. It is a 17-oxo steroid, an enol, a hydroxy steroid and a 3-oxo-Delta(4) steroid. It derives from a hydride of an androstane.

Source: ChEBI

Identity
Molecular formulaC19H26O3
Molecular weight302.4 g/mol
IUPAC name(8R,9S,10R,13S,14S)-4-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione
InChIKeyOSVMTWJCGUFAOD-KZQROQTASA-N
SMILESC[C@]12CCC(=O)C(=C1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CCC4=O)C)O

Computed by PubChem (NCBI)

Synonyms: formestane, 4-Hydroxyandrost-4-ene-3,17-dione, 4-Hydroxyandrostenedione, Lentaron, 4-Hydroxy-4-androstene-3,17-dione, formestano, formestanum, 4-oh-androstene-3,17-dione, 4-hydroxy-Delta(4)-androstenedione, 4-hydroxyandrostene-3,17-dione
Isomers (same molecular formula)
(2-methyl-4-oxo-3-prop-2-enylcyclopent-2-en-1-yl) 2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropane-1-carboxylate C19H26O3
(3E)-3-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]oxolan-2-one C19H26O3
cis-[(1S)-2-methyl-4-oxo-3-prop-2-enylcyclopent-2-en-1-yl] (1R,3R)-2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropane-1-carboxylate C19H26O3
(8R,9S,13S,14S,16R,17S)-3-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-16,17-diol C19H26O3
(2-methyl-4-oxo-3-prop-2-enylcyclopent-2-en-1-yl) 2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropane-1-carboxylate C19H26O3
(8S,9R,10S,13S,14S)-9-hydroxy-10,13-dimethyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,17-dione C19H26O3
(8S,9S,10R,11R,13S,14S)-11-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione C19H26O3
(5S,8R,9S,10S,13S,14S)-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15-dodecahydrocyclopenta[a]phenanthrene-3,16,17-trione C19H26O3
(8S,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-2,6,7,8,9,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3,11-dione C19H26O3
(8R,9S,10S,13S,14S)-10-(hydroxymethyl)-13-methyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione C19H26O3
(8R,9S,13S,14S,16R,17R)-3-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-16,17-diol C19H26O3
(8R,9S,10R,13S,14S,15S)-13-ethyl-15-hydroxy-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-3,17-dione C19H26O3

Also listed as

Formestane, min. 95 %, 5 g Roth CAS 566-48-3
Formestane, >95% (HPLC) TRC CAS 566-48-3
Formestane, min. 95 %, 2 g Roth CAS 566-48-3
Formestane, min. 95 %, 10 g Roth CAS 566-48-3
Formestane, min. 95 %, 25 g Roth CAS 566-48-3