Products 209984-57-6

CAS 209984-57-6 appears in our catalog under these names: LY-411575/ 97.03% (existing batch purity), LY–411575, LY 411575, LY-411575, >95.0%(HPLC)(qNMR), LY411575, 98%, 98%. Offered by: TargetMol, GLPBio, Biosynth, TCI, Chemat. Available pack sizes: 2mg, 5mg, 10mg, 25mg, 50mg, 100mg, 10mM (in 1ml dmso), 1000mg.

LY-411575/ 97.03% (existing batch purity)
TargetMol
  • size: 2mg, 5mg, 10mg, 25mg
  • Variants: 6
from 439.25
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LY–411575
GLPBio
  • size: 10mg, 100mg, 5mg, 10mM (in 1ml dmso)
  • Variants: 5
from 831.06
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LY 411575
Biosynth
  • size: 10mg, 50mg, 1000mg
  • Variants: 3
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LY-411575, >95.0%(HPLC)(qNMR)
TCI
  • size: 5mg
  • Variants: 1
from 360.78
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LY411575, 98%, 98%
Chemat
  • size: 1mg, 5mg, 10mg, 25mg
  • Variants: 7
from 232.40
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LY-411575, 98.68%
MedChemExpress
  • size: 25 mg, 1 g, 10 mg, 50 mg
  • Variants: 7
from 491.52
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LY-411575, 98%
Ambeed
  • size: 1mg, 10mg, 25mg, 50mg
  • Variants: 5
from 298.06
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(S)-2-((S)-2-(3,5-Difluorophenyl)-2-hydroxyacetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propanamide, 98%
Fluorochem
  • size: 1mg, 5mg, 25mg
  • Variants: 3
from 414.46
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Structural formula: {0} (CAS {1})

LY-411575 is a dibenzoazepine that is 5,7-dihydro-6H-dibenzo[b,d]azepin-6-one which is substituted at the 7 pro-S position by the C-terminal carboxamide nitrogen of N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]-L-alaninamide. It is a potent, cell permeable and selective gamma-secretase inhibitor. It has been tested as a possible treatment for Alzheimer's disease and shows promise for its potential to counteract severe hearing loss. It has a role as an EC 3.4.23.46 (memapsin 2) inhibitor. It is a lactam, a secondary alcohol, a difluorobenzene and a dibenzoazepine.

Source: ChEBI

Identity
Molecular formulaC26H23F2N3O4
Molecular weight479.5 g/mol
IUPAC name(2S)-2-[[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide
InChIKeyULSSJYNJIZWPSB-CVRXJBIPSA-N
SMILESC[C@@H](C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)[C@H](C4=CC(=CC(=C4)F)F)O

Computed by PubChem (NCBI)

Synonyms: orb1225693, orb1301106
Related forms of this compound
(2R)-2-[[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide C26H23F2N3O4
(2R)-2-[[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide C26H23F2N3O4
(2S)-2-[[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide C26H23F2N3O4