CAS 1162656-22-5 appears in our catalog under these names: MCB–613, MCB-613, 98%, MCB-613/ 98.17% (existing batch purity), MCB-613, MCB-613, 98%, 98%. Offered by: GLPBio, AmBeed, TargetMol, Biosynth, Chemat. Available pack sizes: 5mg, 2mg, 10mg, 25mg, 50mg, 100mg, 200mg, 10mM (in 1ml dmso).
MCB-613 is a cyclic ketone that is 4-ethylcyclohexanone which is substituted by pyridin-3-ylmethylene groups at positions 2 and 6. It is a potent small molecule stimulator of steroid receptor coactivators (SRCs). MCB-613 increases SRCs' interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species. Since cancer cells overexpress SRCs and rely on them for growth, MCB-613 can be used to selectively induce excessive stress in cancer cells. It has a role as an antineoplastic agent and a steroid receptor coactivator stimulator. It is a member of pyridines, a cyclic ketone and an enone.
Source: ChEBI
| Molecular formula | C20H20N2O |
|---|---|
| Molecular weight | 304.4 g/mol |
| IUPAC name | (2E,6E)-4-ethyl-2,6-bis(pyridin-3-ylmethylidene)cyclohexan-1-one |
| InChIKey | MMBSCBVEHMETSA-GDAWTGGTSA-N |
| SMILES | CCC1C/C(=C\C2=CN=CC=C2)/C(=O)/C(=C/C3=CN=CC=C3)/C1 |
Computed by PubChem (NCBI)