Products 1360614-48-7

CAS 1360614-48-7 appears in our catalog under these names: Necrosulfonamide, Necrosulfonamide/ 99.49% (existing batch purity), Necrosulfonamide, >95.0%(HPLC), Necrosulfonamide 98+%, Necrosulfonamide, 98+%, 98+%. Offered by: GLPBio, TargetMol, Chemat, TCI, Ambeed. Available pack sizes: 10mM (in 1ml dmso), 10mg, 100mg, 25mg, 5mg, 50mg, 500mg, 1mg.

Necrosulfonamide
GLPBio, Chemat
  • size: 10mM (in 1ml dmso), 10mg, 100mg, 25mg
  • Variants: 8
from 504.31
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Necrosulfonamide/ 99.49% (existing batch purity)
TargetMol
  • size: 5mg, 10mg, 25mg, 50mg
  • Variants: 6
from 525.34
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Necrosulfonamide, >95.0%(HPLC)
TCI
  • size: 25mg
  • Variants: 1
from 501.89
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Necrosulfonamide 98+%
Ambeed
  • size: 1mg, 5mg, 10mg, 50mg
  • Variants: 7
from 159.00
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Necrosulfonamide, 98+%, 98+%
Chemat
  • size: 1mg, 5mg, 50mg, 100mg
  • Variants: 5
from 93.20
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Necrosulfonamide, 99.47%
MedChemExpress
  • size: 25 mg, 5 mg, 50 mg, 10mM/1mL
  • Variants: 6
from 500.81
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Necrosulfonamide (Standard)
MedChemExpress
  • size: Get quote
  • Variants: 1
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Structural formula: {0} (CAS {1})

Necrosulfonamide is a sulfonamide that is a 3-methoxypyrazin-2-yl derivative of (E)-N-(4-(N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide. Necrosulfonamide specifically blocks necrosis downstream of the activation of RIP3 (the receptor-interacting serine-threonine kinase 3), a key signalling molecule in the programmed necrosis (necroptosis) pathway. It has a role as a necroptosis inhibitor and a neuroprotective agent. It is a member of thiophenes, a sulfonamide and a member of pyrazines.

Source: ChEBI

Identity
Molecular formulaC18H15N5O6S2
Molecular weight461.5 g/mol
IUPAC name(E)-N-[4-[(3-methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophen-2-yl)prop-2-enamide
InChIKeyFNPPHVLYVGMZMZ-XBXARRHUSA-N
SMILESCOC1=NC=CN=C1NS(=O)(=O)C2=CC=C(C=C2)NC(=O)/C=C/C3=CC=C(S3)[N+](=O)[O-]

Computed by PubChem (NCBI)

Synonyms: Necrosulfonamide, (E/Z)-Necrosulfonamide, Necrosulfonarnide, Necrosulfonamide (NSA)?, orb1220501, orb1226452, orb1300359, MLKL Inhibitor, Necrosulfonamide
Related forms of this compound
(E)-N-[4-[(3-methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophen-2-yl)prop-2-enamide C18H15N5O6S2
(E)-3-(5-nitrothiophen-2-yl)-N-[2,3,5,6-tetradeuterio-4-[(3-methoxypyrazin-2-yl)sulfamoyl]phenyl]prop-2-enamide C18H15N5O6S2