PAC 1

cas: 315183-21-2 — see every product listed under this CAS number, including other names

PAC 1 (CAS 315183-21-2) is a chemical reagent available from Chemat. Available pack sizes: 25mg, 50mg, 100mg, 250mg. Offered by: Biosynth.

brandBiosynth
catalog numberFP15826-25mg
cas315183-21-2
size25mg
Need more information?

Ask us about this product — we're happy to help.

Available pack sizes

brand size price
Biosynth 25mg price on request
Biosynth 50mg price on request
Biosynth 100mg price on request
Biosynth 250mg price on request

properties

categoryLife Sciences
sub-category 1Ligands
sub-category 2Enzyme Modulators
purityNo data
delivery time1-2 weeks
Structural formula: {0} (CAS {1})

Pac-1 is procaspase Activating Compound-1 VO-100 is an orally bioavailable procaspase activating compound-1 (PAC-1), with potential proapoptotic and antineoplastic activities. Upon administration, VO-100 binds to and forms a chelating complex with zinc (Zn) ions inside cells, which prevents the binding of Zn ions to procaspase-3 (PC3) and abrogates the Zn-mediated inhibition of PC3. This allows for the proteolytic autoactivation of PC3 into the active form caspase-3. This results in the selective caspase-3-mediated induction of apoptosis and cell death in cancer cells. In addition, VO-100 is able to cross the blood-brain-barrier (BBB). PC3, a Zn-inhibited proenzyme, is upregulated in a variety of cancer cell types, while its expression is minimal in normal healthy cells.

Source: ChEBI

Identity
Molecular formulaC23H28N4O2
Molecular weight392.5 g/mol
IUPAC name2-(4-benzylpiperazin-1-yl)-N-[(E)-(2-hydroxy-3-prop-2-enylphenyl)methylideneamino]acetamide
InChIKeyYQNRVGJCPCNMKT-LFVJCYFKSA-N
SMILESC=CCC1=C(C(=CC=C1)/C=N/NC(=O)CN2CCN(CC2)CC3=CC=CC=C3)O

Computed by PubChem (NCBI)

Synonyms: Procaspase-activating compound 1, Procaspase Activating Compound-1 VO-100, Procaspase activating compound 1, Procaspase-3 Activator, (E)-N'-(3-allyl-2-hydroxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide, N'-(3-allyl-2-hydroxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide, methylene]hydrazide; Procaspase Activating Compound 1, 4-(Phenylmethyl)-1-piperazineacetic Acid 2-[[2-Hydroxy-3-(2-propen-1-yl)phenyl], pac-1?, orb1225331
Isomers (same molecular formula)
[4-[(4-benzoylpiperazin-1-yl)methyl]piperazin-1-yl]-phenylmethanone C23H28N4O2
3-[2-[4-(1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one C23H28N4O2
tert-butyl 4-(imidazo[1,2-a]pyridin-3-ylmethyl)-3-phenylpiperazine-1-carboxylate C23H28N4O2
5-[2-[4-[(4-propan-2-ylphenyl)methyl]piperazin-1-yl]acetyl]-1,3-dihydrobenzimidazol-2-one C23H28N4O2

Also listed as

PAC-1, >95% (HPLC) TRC CAS 315183-21-2
PAC-1/ 98% TargetMol CAS 315183-21-2
PAC–1 GLPBio CAS 315183-21-2
PAC-1 Sigma-Aldrich CAS 315183-21-2
PAC-1, 98%, 98% Chemat CAS 315183-21-2
PAC-1, 99.88% MedChemExpress CAS 315183-21-2