PAC-1, 99.88%
cas: 315183-21-2 — see every product listed under this CAS number, including other names
PAC-1, 99.88% (CAS 315183-21-2) is a chemical reagent available from Chemat. Available pack sizes: 5 mg, 10 mg, 500 mg, 50 mg, 100 mg, 10mM/1mL. Offered by: MedChemExpress.
| brand | MedChemExpress |
|---|---|
| catalog number | HY-13523-5 mg |
| cas | 315183-21-2 |
| size | 5 mg |
| availability | In stock |
Need more information?
Ask us about this product — we're happy to help.
Available pack sizes
| brand | size | price | |
|---|---|---|---|
| MedChemExpress | 5 mg | 282.54 Pln | |
| MedChemExpress | 10 mg | 384.71 Pln | |
| MedChemExpress | 500 mg | 5395.58 Pln | |
| MedChemExpress | 50 mg | 858.40 Pln | |
| MedChemExpress | 100 mg | 1438.90 Pln | |
| MedChemExpress | 10mM/1mL | 296.47 Pln |
properties
| delivery time | 2-3 weeks |
|---|---|
| purity | 99.88% |
Pac-1 is procaspase Activating Compound-1 VO-100 is an orally bioavailable procaspase activating compound-1 (PAC-1), with potential proapoptotic and antineoplastic activities. Upon administration, VO-100 binds to and forms a chelating complex with zinc (Zn) ions inside cells, which prevents the binding of Zn ions to procaspase-3 (PC3) and abrogates the Zn-mediated inhibition of PC3. This allows for the proteolytic autoactivation of PC3 into the active form caspase-3. This results in the selective caspase-3-mediated induction of apoptosis and cell death in cancer cells. In addition, VO-100 is able to cross the blood-brain-barrier (BBB). PC3, a Zn-inhibited proenzyme, is upregulated in a variety of cancer cell types, while its expression is minimal in normal healthy cells.
Source: ChEBI
| Molecular formula | C23H28N4O2 |
|---|---|
| Molecular weight | 392.5 g/mol |
| IUPAC name | 2-(4-benzylpiperazin-1-yl)-N-[(E)-(2-hydroxy-3-prop-2-enylphenyl)methylideneamino]acetamide |
| InChIKey | YQNRVGJCPCNMKT-LFVJCYFKSA-N |
| SMILES | C=CCC1=C(C(=CC=C1)/C=N/NC(=O)CN2CCN(CC2)CC3=CC=CC=C3)O |
Computed by PubChem (NCBI)
Synonyms:
Procaspase-activating compound 1, Procaspase Activating Compound-1 VO-100, Procaspase activating compound 1, Procaspase-3 Activator, (E)-N'-(3-allyl-2-hydroxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide, N'-(3-allyl-2-hydroxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide, methylene]hydrazide; Procaspase Activating Compound 1, 4-(Phenylmethyl)-1-piperazineacetic Acid 2-[[2-Hydroxy-3-(2-propen-1-yl)phenyl], pac-1?, orb1225331