PAC-1, >95% (HPLC)
cas: 315183-21-2 — see every product listed under this CAS number, including other names
PAC-1, >95% (HPLC) (CAS 315183-21-2) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 25mg, 5mg. Offered by: TRC.
| brand | TRC |
|---|---|
| catalog number | TRC-P132000-10MG |
| cas | 315183-21-2 |
| size | 10mg |
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Available pack sizes
| brand | size | price | |
|---|---|---|---|
| TRC | 10mg | price on request | |
| TRC | 25mg | price on request | |
| TRC | 5mg | price on request |
properties
| purity | >95% (HPLC) |
|---|---|
| delivery time | To be confirmed by Chemat |
Pac-1 is procaspase Activating Compound-1 VO-100 is an orally bioavailable procaspase activating compound-1 (PAC-1), with potential proapoptotic and antineoplastic activities. Upon administration, VO-100 binds to and forms a chelating complex with zinc (Zn) ions inside cells, which prevents the binding of Zn ions to procaspase-3 (PC3) and abrogates the Zn-mediated inhibition of PC3. This allows for the proteolytic autoactivation of PC3 into the active form caspase-3. This results in the selective caspase-3-mediated induction of apoptosis and cell death in cancer cells. In addition, VO-100 is able to cross the blood-brain-barrier (BBB). PC3, a Zn-inhibited proenzyme, is upregulated in a variety of cancer cell types, while its expression is minimal in normal healthy cells.
Source: ChEBI
| Molecular formula | C23H28N4O2 |
|---|---|
| Molecular weight | 392.5 g/mol |
| IUPAC name | 2-(4-benzylpiperazin-1-yl)-N-[(E)-(2-hydroxy-3-prop-2-enylphenyl)methylideneamino]acetamide |
| InChIKey | YQNRVGJCPCNMKT-LFVJCYFKSA-N |
| SMILES | C=CCC1=C(C(=CC=C1)/C=N/NC(=O)CN2CCN(CC2)CC3=CC=CC=C3)O |
Computed by PubChem (NCBI)
Synonyms:
Procaspase-activating compound 1, Procaspase Activating Compound-1 VO-100, Procaspase activating compound 1, Procaspase-3 Activator, (E)-N'-(3-allyl-2-hydroxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide, N'-(3-allyl-2-hydroxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide, methylene]hydrazide; Procaspase Activating Compound 1, 4-(Phenylmethyl)-1-piperazineacetic Acid 2-[[2-Hydroxy-3-(2-propen-1-yl)phenyl], pac-1?, orb1225331