PAC–1

cas: 315183-21-2 — see every product listed under this CAS number, including other names

PAC–1 (CAS 315183-21-2) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 100mg, 25mg, 250mg, 10mM (in 1ml dmso), 50mg. Offered by: GLPBio.

brandGLPBio
catalog numberGC11993-10
cas315183-21-2
size10mg
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Available pack sizes

brand size price
GLPBio 10mg 573.64 Pln
GLPBio 100mg 1219.55 Pln
GLPBio 25mg 671.93 Pln
GLPBio 250mg 2801.56 Pln
GLPBio 10mM (in 1ml dmso) 587.68 Pln
GLPBio 50mg 896.59 Pln

properties

purityNo data
delivery timeTo be confirmed by Chemat
Structural formula: {0} (CAS {1})

Pac-1 is procaspase Activating Compound-1 VO-100 is an orally bioavailable procaspase activating compound-1 (PAC-1), with potential proapoptotic and antineoplastic activities. Upon administration, VO-100 binds to and forms a chelating complex with zinc (Zn) ions inside cells, which prevents the binding of Zn ions to procaspase-3 (PC3) and abrogates the Zn-mediated inhibition of PC3. This allows for the proteolytic autoactivation of PC3 into the active form caspase-3. This results in the selective caspase-3-mediated induction of apoptosis and cell death in cancer cells. In addition, VO-100 is able to cross the blood-brain-barrier (BBB). PC3, a Zn-inhibited proenzyme, is upregulated in a variety of cancer cell types, while its expression is minimal in normal healthy cells.

Source: ChEBI

Identity
Molecular formulaC23H28N4O2
Molecular weight392.5 g/mol
IUPAC name2-(4-benzylpiperazin-1-yl)-N-[(E)-(2-hydroxy-3-prop-2-enylphenyl)methylideneamino]acetamide
InChIKeyYQNRVGJCPCNMKT-LFVJCYFKSA-N
SMILESC=CCC1=C(C(=CC=C1)/C=N/NC(=O)CN2CCN(CC2)CC3=CC=CC=C3)O

Computed by PubChem (NCBI)

Synonyms: Procaspase-activating compound 1, Procaspase Activating Compound-1 VO-100, Procaspase activating compound 1, Procaspase-3 Activator, (E)-N'-(3-allyl-2-hydroxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide, N'-(3-allyl-2-hydroxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide, methylene]hydrazide; Procaspase Activating Compound 1, 4-(Phenylmethyl)-1-piperazineacetic Acid 2-[[2-Hydroxy-3-(2-propen-1-yl)phenyl], pac-1?, orb1225331
Isomers (same molecular formula)
[4-[(4-benzoylpiperazin-1-yl)methyl]piperazin-1-yl]-phenylmethanone C23H28N4O2
3-[2-[4-(1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one C23H28N4O2
tert-butyl 4-(imidazo[1,2-a]pyridin-3-ylmethyl)-3-phenylpiperazine-1-carboxylate C23H28N4O2
5-[2-[4-[(4-propan-2-ylphenyl)methyl]piperazin-1-yl]acetyl]-1,3-dihydrobenzimidazol-2-one C23H28N4O2

Also listed as

PAC-1, >95% (HPLC) TRC CAS 315183-21-2
PAC-1/ 98% TargetMol CAS 315183-21-2
PAC 1 Biosynth CAS 315183-21-2
PAC-1 Sigma-Aldrich CAS 315183-21-2
PAC-1, 98%, 98% Chemat CAS 315183-21-2
PAC-1, 99.88% MedChemExpress CAS 315183-21-2