PLpro inhibitor

cas: 1093070-14-4 — see every product listed under this CAS number, including other names

PLpro inhibitor (CAS 1093070-14-4) is a chemical reagent available from Chemat. Available pack sizes: 50mg, 5mg, 10mg, 25mg, 100mg. Offered by: Biosynth.

brandBiosynth
catalog numberBP178805-50mg
cas1093070-14-4
size50mg
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properties

categoryLife Sciences
sub-category 1Ligands
sub-category 2Other Targets
purityNo data
delivery time1-2 weeks
Structural formula: {0} (CAS {1})

KOM70144 is a benzamide that is GRL-0617 in which one of the hydrogen's of the primary amino group is replaced by an acetyl group. It an inhibitor of SARS-CoV and SARS-CoV-2 papain-like protease (PLpro) with an IC50 of 2.6 M and 5.0 M, respectively. It also inhibits SARS-CoV and SARS-CoV-2 infection of Vero E6 cells in vitro (EC50 values are 13.1 and 21 M, respectively). It has a role as an anticoronaviral agent and a protease inhibitor. It is a secondary carboxamide, a member of acetamides, a member of benzamides and a member of naphthalenes. It is functionally related to a GRL-0617.

Source: ChEBI

Identity
Molecular formulaC22H22N2O2
Molecular weight346.4 g/mol
IUPAC name5-acetamido-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide
InChIKeyKGPYBLOBHQLIET-OAHLLOKOSA-N
SMILESCC1=C(C=C(C=C1)NC(=O)C)C(=O)N[C@H](C)C2=CC=CC3=CC=CC=C32

Computed by PubChem (NCBI)

Synonyms: (R)-5-acetamido-2-methyl-N-(1-(naphthalen-1-yl)ethyl)benzamide, 5-(acetylamino)-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]benzamide, 5-N-Acetylamino-2-methyl-N-[(R)-1-(1-naphthyl)ethyl]benzamide, 5-acetamido-2-methyl-N-((1R)-1-(naphthalen-1-yl)ethyl)benzamide, 5-N-acetylamino-2-methyl-N-((R)-1-(1-naphthyl)ethyl)benzamide, 5-(Acetylamino)-2-methyl-N-((1R)-1-(1-naphthalenyl)ethyl)benzamide, PLpro inhibitor, 5-acetamido-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide, PLpro inhibitor 6, orb1219969
Isomers (same molecular formula)
tert-butyl 1-(1H-indol-3-yl)-1H-isoquinoline-2-carboxylate C22H22N2O2
benzyl 3-naphthalen-2-ylpiperazine-1-carboxylate C22H22N2O2
(4S)-4-phenyl-2-[1-[(4S)-4-phenyl-4,5-dihydro-1,3-oxazol-2-yl]cyclobutyl]-4,5-dihydro-1,3-oxazole C22H22N2O2
2,2-bis(1H-indol-3-yl)ethyl butanoate C22H22N2O2
2,5-bis(2,6-dimethylanilino)cyclohexa-2,5-diene-1,4-dione C22H22N2O2

Also listed as

5-Acetylamino-2-methyl-n-(1r-naphthalen-1-yl-ethyl)-benzamide, 95% Combi-blocks CAS 1093070-14-4
PLpro inhibitor/ 99.82% (existing batch purity) TargetMol CAS 1093070-14-4
PLpro inhibitor 99% Ambeed CAS 1093070-14-4
5-(Acetylamino)-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]benzamide, 99%, 99% Chemat CAS 1093070-14-4
PLpro inhibitor, 99.88% MedChemExpress CAS 1093070-14-4