Products 1093070-14-4
CAS 1093070-14-4 appears in our catalog under these names: 5-Acetylamino-2-methyl-n-(1r-naphthalen-1-yl-ethyl)-benzamide, 95%, PLpro inhibitor/ 99.82% (existing batch purity), PLpro inhibitor, PLpro inhibitor 99%, 5-(Acetylamino)-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]benzamide, 99%, 99%. Offered by: Combi-blocks, TargetMol, Biosynth, Ambeed, Chemat. Available pack sizes: 100mg, 1mg, 5mg, 10mg, 25mg, 50mg, 250mg, 2mg.
KOM70144 is a benzamide that is GRL-0617 in which one of the hydrogen's of the primary amino group is replaced by an acetyl group. It an inhibitor of SARS-CoV and SARS-CoV-2 papain-like protease (PLpro) with an IC50 of 2.6 M and 5.0 M, respectively. It also inhibits SARS-CoV and SARS-CoV-2 infection of Vero E6 cells in vitro (EC50 values are 13.1 and 21 M, respectively). It has a role as an anticoronaviral agent and a protease inhibitor. It is a secondary carboxamide, a member of acetamides, a member of benzamides and a member of naphthalenes. It is functionally related to a GRL-0617.
Source: ChEBI
| Molecular formula | C22H22N2O2 |
|---|---|
| Molecular weight | 346.4 g/mol |
| IUPAC name | 5-acetamido-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide |
| InChIKey | KGPYBLOBHQLIET-OAHLLOKOSA-N |
| SMILES | CC1=C(C=C(C=C1)NC(=O)C)C(=O)N[C@H](C)C2=CC=CC3=CC=CC=C32 |
Computed by PubChem (NCBI)
Synonyms:
(R)-5-acetamido-2-methyl-N-(1-(naphthalen-1-yl)ethyl)benzamide, 5-(acetylamino)-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]benzamide, 5-N-Acetylamino-2-methyl-N-[(R)-1-(1-naphthyl)ethyl]benzamide, 5-acetamido-2-methyl-N-((1R)-1-(naphthalen-1-yl)ethyl)benzamide, 5-N-acetylamino-2-methyl-N-((R)-1-(1-naphthyl)ethyl)benzamide, 5-(Acetylamino)-2-methyl-N-((1R)-1-(1-naphthalenyl)ethyl)benzamide, PLpro inhibitor, 5-acetamido-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide, PLpro inhibitor 6, orb1219969