CAS 1114544-31-8 appears in our catalog under these names: 3-(2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl)-4-methyl-n-(4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl)benzamide hydrochloride, 95%, Ponatinib Hydrochloride, >95% (HPLC), Ponatinib Hydrochloride/ 100%, Ponatinib (hydrochloride), Ponatinib HCl. Offered by: Combi-blocks, TRC, TargetMol, GLPBio, Biosynth. Available pack sizes: 100mg, 250mg, 50mg, 25mg, 200mg, 500mg, 1g, 2g.
Ponatinib hydrochloride is the hydrochloride salt of ponatinib. It is a potent pan inhibitor of tyrosine kinases, active in all single resistance ABL kinase mutations including the T315l mutation. It is approved for the treatment of chronic myeloid leukemia. It has a role as an antineoplastic agent and a tyrosine kinase inhibitor. It contains a ponatinib(1+).
Source: ChEBI
| Molecular formula | C29H28ClF3N6O |
|---|---|
| Molecular weight | 569.0 g/mol |
| IUPAC name | 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide;hydrochloride |
| InChIKey | BWTNNZPNKQIADY-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5.Cl |
Computed by PubChem (NCBI)