Products 1096708-71-2
CAS 1096708-71-2 appears in our catalog under these names: MLN 2480, MLN2480, TAK-580/ 99.25% (existing batch purity), BIIB-024, Tovorafenib 99%. Offered by: GLPBio, TRC, TargetMol, Biosynth, Ambeed. Available pack sizes: 2mg, 10mg, 1mg, 25mg, 100mg, 5mg, 10mM (in 1ml dmso), 50mg.
TAK-580 is a 1,3-thiazolecarboxamide that is 2-[(1R)-1-aminoethyl]-1,3-thiazole-5-carboxylic acid in which the carboxy group undergoes formal condensation with the amino group of 5-chloro-4-(trifluoromethyl)pyridin-2-amine and in which the amino group undergoes formal condensation with the carboxy group of 6-amino-5-chloropyrimidine-4-carboxylic acid. It is a pan-RAF kinase inhibitor which is currently in clinical development for the treatment of radiographically recurrent or progressive low-grade glioma in children and young adults. It has a role as an antineoplastic agent, an apoptosis inducer and a B-Raf inhibitor. It is a secondary carboxamide, an organofluorine compound, an aminopyrimidine, a chloropyridine, a pyrimidinecarboxamide and a 1,3-thiazolecarboxamide.
Source: ChEBI
| Molecular formula | C17H12Cl2F3N7O2S |
|---|---|
| Molecular weight | 506.3 g/mol |
| IUPAC name | 2-[(1R)-1-[(6-amino-5-chloropyrimidine-4-carbonyl)amino]ethyl]-N-[5-chloro-4-(trifluoromethyl)-2-pyridinyl]-1,3-thiazole-5-carboxamide |
| InChIKey | VWMJHAFYPMOMGF-ZCFIWIBFSA-N |
| SMILES | C[C@H](C1=NC=C(S1)C(=O)NC2=NC=C(C(=C2)C(F)(F)F)Cl)NC(=O)C3=C(C(=NC=N3)N)Cl |
Computed by PubChem (NCBI)