Products 1187431-43-1

CAS 1187431-43-1 appears in our catalog under these names: Trametinib Dimethyl Sulfoxide, Trametinib (DMSO Solvate), >95% (HPLC), Trametinib (DMSO solvate)/ 100%, Trametinib DMSO solvate, GSK 1120212B. Offered by: Chemat Brand, TRC, TargetMol, GLPBio, Biosynth. Available pack sizes: on request, 100mg, 1g, 500mg, 10mg, 25mg, 50mg, 200mg.

Trametinib Dimethyl Sulfoxide
Chemat Brand
  • size: on request
  • Variants: 1
View product
Trametinib (DMSO Solvate), >95% (HPLC)
TRC
  • size: 100mg, 1g, 500mg
  • Variants: 3
View product
Trametinib (DMSO solvate)/ 100%
TargetMol
  • size: 10mg, 25mg, 50mg, 100mg
  • Variants: 5
from 452.11
View product
Trametinib DMSO solvate
GLPBio
  • size: 10mg, 100mg, 10mM (in 1ml dmso), 50mg
  • Variants: 4
from 817.02
View product
GSK 1120212B
Biosynth
  • size: 250mg, 100mg, 500mg
  • Variants: 3
View product
Trametinib, 98.00%
Chemat
  • size: 10mg
  • Variants: 1
from 800.29
View product
Trametinib (DMSO solvate) 98%
Ambeed
  • size: 1mg, 5mg, 250mg, 1g
  • Variants: 5
from 120.06
View product
Trametinib DMSO solvate, 98%, 98%
Chemat
  • size: 50mg, 100mg, 250mg, 1g
  • Variants: 5
from 141.20
View product
Trametinib (DMSO solvate), 99.56%
MedChemExpress
  • size: 100 mg, 10 mg, 5 mg, 50 mg
  • Variants: 4
from 273.25
View product
GSK 1120212B, min. 95 %, 100 mg
Roth
  • size: 100mg
  • Variants: 1
from 844.81
View product
GSK 1120212B, min. 95 %, 250 mg
Roth
  • size: 250mg
  • Variants: 1
from 1675.46
View product
GSK 1120212B, min. 95 %, 500 mg
Roth
  • size: 500mg
  • Variants: 1
from 2949.76
View product

Trametinib dimethyl sulfoxide is an addition compound obtained by combining equimolar amounts of trametinib and dimethyl sulfoxide. Used for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations, and who have not received prior BRAF inhibitor treatment. It has a role as an antineoplastic agent and an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor. It contains a dimethyl sulfoxide and a trametinib.

Source: ChEBI

Identity
Molecular formulaC28H29FIN5O5S
Molecular weight693.5 g/mol
IUPAC nameN-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide;methylsulfinylmethane
InChIKeyOQUFJVRYDFIQBW-UHFFFAOYSA-N
SMILESCC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5.CS(=O)C

Computed by PubChem (NCBI)

Synonyms: TRAMETINIB DIMETHYL SULFOXIDE, Trametinib DMSO, Mekinst, Trametinib DMSO solvate, Trametinib (DMSO solvate), Trametinib dimethyl sulfoxide [USAN], Spexotras (TN), Mekinist (TN), Trametinib Impurity 28, Trametinib DMSO solvate?