Products 137281-23-3

CAS 137281-23-3 appears in our catalog under these names: Pemetrexed, N-(4-(2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoyl)-L-glutamic Acid, >95% (HPLC), Pemetrexed/ 100%, Pemetrexed, >98.0%(HPLC)(T), Pemetrexed - Bio-X â„¢. Offered by: Chemat Brand, TRC, TargetMol, Biosynth, TCI. Available pack sizes: on request, 2,5g, 250mg, 25mg, 50mg, 100mg, 200mg, 500mg.

Pemetrexed
Chemat Brand, Biosynth
  • size: on request, 1g, 2g, 5g
  • Variants: 6
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N-(4-(2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoyl)-L-glutamic Acid, >95% (HPLC)
TRC
  • size: 2,5g, 250mg
  • Variants: 2
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Pemetrexed/ 100%
TargetMol
  • size: 25mg, 50mg, 100mg, 200mg
  • Variants: 5
from 405.71
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Pemetrexed, >98.0%(HPLC)(T)
TCI
  • size: 250mg, 1g
  • Variants: 2
from 231.44
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Pemetrexed - Bio-X â„¢
Biosynth
  • size: 50mg
  • Variants: 1
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Pemetrexed 99+%
Ambeed
  • size: 1mg, 100mg, 250mg, 1g
  • Variants: 5
from 131.19
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Pemetrexed 98% +(contains <4%EtOH)(Loss on drying≤6%)
Ambeed
  • size: 1g, 5g, 25g
  • Variants: 3
from 264.69
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N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamicacid, 99+%, 99+%
Chemat
  • size: 250mg, 1g, 5g, 1mg
  • Variants: 4
from 78.80
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Pemetrexed, 99.95%
MedChemExpress
  • size: 500 mg, 100 mg, 10mM/1mL, 50 mg
  • Variants: 5
from 407.93
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Pemetrexed (Standard), 99.09%
MedChemExpress
  • size: 100 mg, 50 mg, 5 mg, 25 mg
  • Variants: 5
from 310.40
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(S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid, 95%
Fluorochem
  • size: 250mg, 1g, 5g
  • Variants: 3
from 174.96
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Structural formula: {0} (CAS {1})

Pemetrexed is an N-acylglutamic acid in which the N-acyl group is specified as 4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). It has a role as an antimetabolite, an antineoplastic agent, an EC 1.5.1.3 (dihydrofolate reductase) inhibitor, an EC 2.1.1.45 (thymidylate synthase) inhibitor and an EC 2.1.2.2 (phosphoribosylglycinamide formyltransferase) inhibitor. It is a N-acyl-L-glutamic acid and a pyrrolopyrimidine. It is a conjugate acid of a pemetrexed(2-).

Source: ChEBI

Identity
Molecular formulaC20H21N5O6
Molecular weight427.4 g/mol
IUPAC name(2S)-2-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid
InChIKeyWBXPDJSOTKVWSJ-ZDUSSCGKSA-N
SMILESC1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)N[C@@H](CCC(=O)O)C(=O)O

Computed by PubChem (NCBI)

Synonyms: Pemetrexed, PEMFEXY, Pemetrexed Sodium, pemetrexedum, AXTLE, Multitargeted Antifolate, PEMETREXED FOR INJECTION, Alimta, Pemetrexed (INN), PEMETREXED [INN]
Related forms of this compound
(2R)-2-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid C20H21N5O6