Products 1421438-81-4

CAS 1421438-81-4 appears in our catalog under these names: LY 3039478, Crenigacestat/ 98.76% (existing batch purity), LY3039478, Crenigacestat 95%, N-[(1S)-2-[[(7S)-6,7-Dihydro-5-(2-hydroxyethyl)-6-oxo-5H-pyrido[3,2-a][3]benzazepin-7-yl]amino]-1-methyl-2-oxoethyl]-4,4,4-trifluorobutanamide, 95%, 95%. Offered by: TRC, TargetMol, GLPBio, Ambeed, Chemat. Available pack sizes: 100mg, 1mg, 5mg, 10mg, 25mg, 2mg, 10mM (in 1ml dmso), 50mg.

LY 3039478
TRC
  • size: 100mg
  • Variants: 1
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Crenigacestat/ 98.76% (existing batch purity)
TargetMol
  • size: 1mg, 5mg, 10mg, 25mg
  • Variants: 4
from 552.17
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LY3039478
GLPBio
  • size: 10mg, 100mg, 2mg, 25mg
  • Variants: 7
from 756.18
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Crenigacestat 95%
Ambeed
  • size: 1mg, 2mg, 5mg, 10mg
  • Variants: 7
from 342.56
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N-[(1S)-2-[[(7S)-6,7-Dihydro-5-(2-hydroxyethyl)-6-oxo-5H-pyrido[3,2-a][3]benzazepin-7-yl]amino]-1-methyl-2-oxoethyl]-4,4,4-trifluorobutanamide, 95%, 95%
Chemat
  • size: 5mg, 10mg, 25mg, 50mg
  • Variants: 5
from 506.00
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Crenigacestat, 99.01%
MedChemExpress
  • size: 10mM/1mL, 1 mg, 10 mg, 100 mg
  • Variants: 7
from 459.01
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Structural formula: {0} (CAS {1})

Crenigacestat (LY3039478) is an orally active Notch and g-secretase inhibitor, with an IC50 of 1 nM in most of the tumor cell lines tested.

Source: ChEBI

Identity
Molecular formulaC22H23F3N4O4
Molecular weight464.4 g/mol
IUPAC name4,4,4-trifluoro-N-[(2S)-1-[[(7S)-5-(2-hydroxyethyl)-6-oxo-7H-pyrido[2,3-d][3]benzazepin-7-yl]amino]-1-oxopropan-2-yl]butanamide
InChIKeyYCBAQKQAINQRFW-UGSOOPFHSA-N
SMILESC[C@@H](C(=O)N[C@H]1C2=CC=CC=C2C3=C(N=CC=C3)N(C1=O)CCO)NC(=O)CCC(F)(F)F

Computed by PubChem (NCBI)

Synonyms: Crenigacestat, crenigacestatum, Gamma-Secretase Inhibitor LY3039478, Crenigacestat [USAN], Crenigacestat (LY3039478), CRENIGACESTAT [INN], Crenigacestat (USAN/INN), CRENIGACESTAT [WHO-DD], orb1226314, orb1303976