Products 168273-06-1
CAS 168273-06-1 appears in our catalog under these names: Rimonabant, min. 95 %, 1 g, Rimonabant, 96%, Rimonabant/ 99.91% (existing batch purity), Rimonabant, Rimonabant base, 98.00%. Offered by: Roth, Combi-blocks, TargetMol, GLPBio, Chemat. Available pack sizes: 1g, 10g, 5g, 25g, 10mg, 25mg, 50mg, 100mg.
Rimonabant is a carbohydrazide obtained by formal condensation of the carboxy group of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. It is a potent and selective cannabinoid receptor 1 (CB1R) antagonist. Besides its antagonistic properties, numerous studies have shown that, at micromolar concentrations rimonabant behaves as an inverse agonist at CB1 receptors. The drug was the first selective CB1 antagonist/inverse agonist introduced into clinical practice to treat obesity and metabolic-related disorders. It was later withdrawn from market due to CNS-related adverse effects including depression and suicidal ideation. It has a role as an appetite depressant, a CB1 receptor antagonist and an anti-obesity agent. It is a dichlorobenzene, a member of pyrazoles, a carbohydrazide, an amidopiperidine and a member of monochlorobenzenes.
Source: ChEBI
| Molecular formula | C22H21Cl3N4O |
|---|---|
| Molecular weight | 463.8 g/mol |
| IUPAC name | 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-piperidin-1-ylpyrazole-3-carboxamide |
| InChIKey | JZCPYUJPEARBJL-UHFFFAOYSA-N |
| SMILES | CC1=C(N(N=C1C(=O)NN2CCCCC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)Cl |
Computed by PubChem (NCBI)