Products 169274-78-6
CAS 169274-78-6 appears in our catalog under these names: Ro 25-6981/ 99.44% (existing batch purity), Ro 25–6981, RO 25-6981 Maleate, (αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol, 97%, 97%, Ro 25-6981, 99.55%. Offered by: TargetMol, GLPBio, Biosynth, Chemat, MedChemExpress. Available pack sizes: 1mg, 2mg, 5mg, 10mg, 25mg, 50mg, 100mg, 500mg.
Ro 25-6981 is a member of the class of piperidines that is 4-benzylpiperidine substituted by a 3-hydroxy-3-(4-hydroxyphenyl)-2-methylpropyl group at position 1 (the 1R,2S-stereoisomer). It is a potent antagonist of the GluN2B subunit of the N-methyl-D-aspartate (NMDA) receptor. It has a role as an antidepressant, an anticonvulsant, a NMDA receptor antagonist and a neuroprotective agent. It is a member of benzenes, a member of piperidines, a member of phenols, a secondary alcohol and a tertiary amino compound. It is a conjugate base of a Ro 25-6981(1+).
Source: ChEBI
| Molecular formula | C22H29NO2 |
|---|---|
| Molecular weight | 339.5 g/mol |
| IUPAC name | 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol |
| InChIKey | WVZSEUPGUDIELE-HTAPYJJXSA-N |
| SMILES | C[C@@H](CN1CCC(CC1)CC2=CC=CC=C2)[C@H](C3=CC=C(C=C3)O)O |
Computed by PubChem (NCBI)
Synonyms:
Ro 25-6981, Ro-25-6981, ro25-6981, Ro 25-6981 free base, 4-[(1R,2S)-1-hydroxy-2-methyl-3-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol, alpha-(4-hydroxyphenyl)-beta-methyl--4-(phenylmethyl)-1-piperidine propanol, 4-((1R,2S)-1-hydroxy-2-methyl-3-(4-(phenylmethyl)-1-piperidinyl)propyl)phenol, Ro25,6981, 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol, 4-((1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl)phenol