Products 1821-12-1
CAS 1821-12-1 appears in our catalog under these names: Phenylbutyrate, 4-Phenylbutyric Acid, >95% (HPLC), 4-Phenylbutyric acid/ 99.76% (existing batch purity), Benzenebutyric acid (4–Phenylbutyric acid), 4-Phenylbutyric acid, 99% . Offered by: Chemat Brand, TRC, TargetMol, GLPBio, Thermo Scientific (Alfa Aesar). Available pack sizes: on request, 2,5g, 500mg, 10mM (in 1ml dmso), 5g, 25g, 100g, 500g.
4-phenylbutyric acid is a monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation. It has a role as an antineoplastic agent, a prodrug, an EC 3.5.1.98 (histone deacetylase) inhibitor and an apoptosis inducer. It is functionally related to a butyric acid. It is a conjugate acid of a 4-phenylbutyrate.
Source: ChEBI
| Molecular formula | C10H12O2 |
|---|---|
| Molecular weight | 164.20 g/mol |
| IUPAC name | 4-phenylbutanoic acid |
| InChIKey | OBKXEAXTFZPCHS-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)CCCC(=O)O |
Computed by PubChem (NCBI)