Products 2095732-06-0
CAS 2095732-06-0 appears in our catalog under these names: CB–1158 (INCB01158), CB-1158, Numidargistat, 98.91%, Numidargistat (Standard), (3R,4S)-3-Amino-1-[(2S)-2-aminopropanoyl]-4-[3-(dihydroxyboranyl)propyl]pyrrolidine-3-carboxylic acid, 98.0%. Offered by: GLPBio, Biosynth, MedChemExpress, Chemat. Available pack sizes: 10mg, 25mg, 5mg, 10g, 5g, 1 mg, 25 mg, 5 mg.
Numidargistat is an aminopyrrolidine that is pyrrolidine substituted by (2S)-2-aminopropanoyl, amino, carboxy, and 3-boronopropyl groups at positions 1, 3, 3, and 4 (the 3R,4S-stereoisomer). It is a selective arginase inhibitor being developed by Calithera Biosciences for the treatment of solid tumours. It has a role as an EC 3.5.3.1 (arginase) inhibitor, an antineoplastic agent and an immunomodulator. It is a member of boronic acids, a N-acylpyrrolidine, a pyrrolidinecarboxylic acid, an aminopyrrolidine, a primary amino compound and an amino monocarboxylic acid.
Source: ChEBI
| Molecular formula | C11H22BN3O5 |
|---|---|
| Molecular weight | 287.12 g/mol |
| IUPAC name | (3R,4S)-3-amino-1-[(2S)-2-aminopropanoyl]-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid |
| InChIKey | ZZJLMZYUGLJBSO-LAEOZQHASA-N |
| SMILES | B(CCC[C@H]1CN(C[C@]1(C(=O)O)N)C(=O)[C@H](C)N)(O)O |
Computed by PubChem (NCBI)