Products 210344-95-9

CAS 210344-95-9 appears in our catalog under these names: Z-Devd-fmk, 95%, Z-DEVD-FMK/ 99.69% (existing batch purity), Z–DEVD–FMK, Z-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone, Z-DEVD-FMK 98%. Offered by: Combi-blocks, TargetMol, GLPBio, Biosynth, Ambeed. Available pack sizes: 1mg, 25mg, 10mg, 5mg, 50mg, 10mM (in 1ml dmso), 5000ug, 2000ug.

Z-Devd-fmk, 95%
Combi-blocks
  • size: 1mg, 25mg, 10mg, 5mg
  • Variants: 4
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Z-DEVD-FMK/ 99.69% (existing batch purity)
TargetMol
  • size: 1mg, 5mg, 10mg, 25mg
  • Variants: 5
from 525.34
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Z–DEVD–FMK
GLPBio
  • size: 1mg, 10mg, 5mg, 10mM (in 1ml dmso)
  • Variants: 4
from 760.86
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Z-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone
Biosynth
  • size: 5000ug, 2000ug, 10000ug
  • Variants: 3
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Z-DEVD-FMK 98%
Ambeed
  • size: 1mg, 5mg, 25mg, 50mg
  • Variants: 6
from 292.50
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Caspase-3 Inhibitor II 1PC X 1MG
Sigma-Aldrich
  • size: 1MG
  • Variants: 1
from 1830.00
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Caspase-3 Inhibitor II 1PC X 250UG
Sigma-Aldrich
  • size: 250UG
  • Variants: 1
from 616.00
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Caspase-3 Inhibitor II 1PC X 5UNMG
Sigma-Aldrich
  • size: 1EA
  • Variants: 1
from 81160.00
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Caspase-3 Inhibitor, 98%, 98%
Chemat
  • size: 1mg, 5mg, 10mg, 25mg
  • Variants: 5
from 237.20
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Z-DEVD-FMK, 98.0%
MedChemExpress
  • size: 1 mg, 10mM/1mL, 10 mg, 5 mg
  • Variants: 4
from 435.79
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Structural formula: {0} (CAS {1})

Z-DEVD-FMK is a tetrapeptide consisting of Fmoc-L-aspartic acid 4-methyl ester, methyl L-alpha-glutamic acid 5-methyl ester, L-valine and the fluoromethyl ketone derived from the 1-carboxy group of L-aspartic acid 4-methyl ester coupled in sequence. It is a specific, irreversible caspase-3 inhibitor that also shows potent inhibition of caspase-6, caspase-7, caspase-8, and caspase-10. It has a role as an EC 3.4.22.56 (caspase-3) inhibitor, a neuroprotective agent and an apoptosis inhibitor.

Source: ChEBI

Identity
Molecular formulaC30H41FN4O12
Molecular weight668.7 g/mol
IUPAC namemethyl (4S)-5-[[(2S)-1-[[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-[[(2S)-4-methoxy-4-oxo-2-(phenylmethoxycarbonylamino)butanoyl]amino]-5-oxopentanoate
InChIKeyGBJVAVGBSGRRKN-JYEBCORGSA-N
SMILESCC(C)[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](CCC(=O)OC)NC(=O)[C@H](CC(=O)OC)NC(=O)OCC1=CC=CC=C1

Computed by PubChem (NCBI)

Synonyms: Z-DEVD-FMK, benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone, N-benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone, benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone, Z-Asp-Glu-Val-Asp-fluoromethyl ketone, Caspase-3 Inhibitor, Z-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone, Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-Fluoromethylketone, Z-D(OMe)E(Ome)VD(OMe)-FMK, Z-DEVD-fluoromethylketone