CAS 437742-34-2 appears in our catalog under these names: (1R,4R,5S)-4-(2-Chloroethyl)-1-[(S)-(1S)-2-cyclohexen-1-ylhydroxymethyl]-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione, 99+%, 99+%, Marizomib (Salinosporamide A), Marizomib, Marizomib/ 98.03% (existing batch purity), Salinosporamide A (NPI–0052, Marizomib). Offered by: Chemat, Chemat Brand, Creative Peptides, TRC, TargetMol. Available pack sizes: 1mg, 5mg, on request, 25mg, 100μg, 100ug, 100 μg, 1 mg.
Salinosporamide A is a salinosporamide in which the core (1R)-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione skeleton is substituted at positions 1, 4, and 5 by (1S)-cyclohex-2-en-1-yl(hydroxy)methyl, 2-chloroethyl, and methyl groups, respectively (the 1R,4R,5S diastereoisomer). A potent proteasome inhibitor, it has attracted interest for potential use in the treatment of various cancers. It has a role as an antineoplastic agent and a proteasome inhibitor. It is an organic heterobicyclic compound, an organochlorine compound, a salinosporamide, a beta-lactone and a gamma-lactam.
Source: ChEBI
| Molecular formula | C15H20ClNO4 |
|---|---|
| Molecular weight | 313.77 g/mol |
| IUPAC name | (1R,4R,5S)-4-(2-chloroethyl)-1-[(S)-[(1S)-cyclohex-2-en-1-yl]-hydroxymethyl]-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione |
| InChIKey | NGWSFRIPKNWYAO-SHTIJGAHSA-N |
| SMILES | C[C@]12[C@H](C(=O)N[C@]1(C(=O)O2)[C@H]([C@H]3CCCC=C3)O)CCCl |
Computed by PubChem (NCBI)