Products 449811-01-2

CAS 449811-01-2 appears in our catalog under these names: Pamapimod, Pamapimod/ 99.99%, Pamapimod (R–1503, Ro4402257), 6-(2,4-Difluorophenoxy)-2-((1,5-dihydroxypentan-3-yl)amino)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, Pamapimod, 99.71%. Offered by: Chemat Brand, TRC, TargetMol, GLPBio, Chemat. Available pack sizes: on request, 1mg, 2mg, 5mg, 10mg, 25mg, 50mg, 100mg.

Pamapimod
Chemat Brand, TRC
  • size: on request, 1mg, 2mg, 5mg
  • Variants: 4
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Pamapimod/ 99.99%
TargetMol
  • size: 1mg, 5mg, 10mg, 25mg
  • Variants: 7
from 518.63
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Pamapimod (R–1503, Ro4402257)
GLPBio
  • size: 10mg, 25mg, 5mg, 10mM (in 1ml dmso)
  • Variants: 4
from 1046.37
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6-(2,4-Difluorophenoxy)-2-((1,5-dihydroxypentan-3-yl)amino)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one
Chemat
  • size: 1mg, 5mg, 100mg, 250mg
  • Variants: 6
from 251.60
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Pamapimod, 99.71%
MedChemExpress
  • size: 25 mg, 10mM/1mL, 50 mg, 100 mg
  • Variants: 6
from 839.82
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Pamapimod (Standard)
MedChemExpress
  • size: 50 mg, 100 mg, 5 mg, 25 mg
  • Variants: 6
from 719.08
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PAMAPIMOD, 99%
Fluorochem
  • size: 1mg, 5mg, 100mg, 250mg
  • Variants: 4
from 404.04
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Structural formula: {0} (CAS {1})

Pamapimod is a member of the class of pyridopyrimidines that is 8-methylpyrido[2,3-d]pyrimidin-7(8H)-one carrying additional (1,5-dihydroxypentan-3-yl)amino and 2,4-difluorophenoxy substituents at positions 2 and 6 respectively. It is a potent inhibitor of MAPK and is used for treatment of rheumatoid arthritis. It has a role as an antirheumatic drug and an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor. It is a primary alcohol, a diol, an aromatic amine, an aromatic ether, a difluorobenzene, a pyridopyrimidine and a secondary amino compound.

Source: ChEBI

Identity
Molecular formulaC19H20F2N4O4
Molecular weight406.4 g/mol
IUPAC name6-(2,4-difluorophenoxy)-2-(1,5-dihydroxypentan-3-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one
InChIKeyJYYLVUFNAHSSFE-UHFFFAOYSA-N
SMILESCN1C2=NC(=NC=C2C=C(C1=O)OC3=C(C=C(C=C3)F)F)NC(CCO)CCO

Computed by PubChem (NCBI)

Synonyms: Pamapimod, Ro4402257, Ro-4402257, pamapimodum, Pamapimod [USAN], Pamapimod (INN/USAN), Pamapimod [USAN:INN], PamapimodR-1503, PamapimodR-1503?, PAMAPIMOD [INN]
Related forms of this compound
6-(2,4-difluorophenoxy)-8-methyl-2-[(1,1,5,5-tetradeuterio-1,5-dihydroxypentan-3-yl)amino]pyrido[2,3-d]pyrimidin-7-one C19H20F2N4O4