Products 660868-91-7
CAS 660868-91-7 appears in our catalog under these names: GW-843682X, GW843682X/ 99.56% (existing batch purity), GW843682X, GW843682X 98%, 5-(5,6-Dimethoxy-1H-benzo[d]imidazol-1-yl)-3-((2-(trifluoromethyl)benzyl)oxy)thiophene-2-carboxamide. Offered by: TRC, TargetMol, GLPBio, Ambeed, Sigma-Aldrich. Available pack sizes: 500mg, 1mg, 2mg, 5mg, 10mg, 25mg, 50mg, 100mg.
GW843682X is a member of the class of benzimidazoles that is 1H-benzimidazole substituted by 5-carbamoyl-4-{[2-(trifluoromethyl)phenyl]methoxy}thiophen-2-yl, methoxy, and methoxy groups at positions 1, 5, and 6, respectively. It is a potent inhibitor of PLK1 and PLK3 (IC50 = 2.2 and 9.1 nM respectively). It has a role as an EC 2.7.11.21 (polo kinase) inhibitor, an antineoplastic agent and an apoptosis inducer. It is a primary carboxamide, a member of benzimidazoles, a member of thiophenes, an aromatic ether and a member of (trifluoromethyl)benzenes.
Source: ChEBI
| Molecular formula | C22H18F3N3O4S |
|---|---|
| Molecular weight | 477.5 g/mol |
| IUPAC name | 5-(5,6-dimethoxybenzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]thiophene-2-carboxamide |
| InChIKey | JSKUWFIZUALZLX-UHFFFAOYSA-N |
| SMILES | COC1=C(C=C2C(=C1)N=CN2C3=CC(=C(S3)C(=O)N)OCC4=CC=CC=C4C(F)(F)F)OC |
Computed by PubChem (NCBI)