CAS 700874-72-2 appears in our catalog under these names: LY2157299, 4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide, 98%, Galunisertib (LY2157299), LY2157299, >95% (HPLC), Galunisertib/ 97.09% (existing batch purity). Offered by: GLPBio, BLDpharm, Chemat Brand, TRC, TargetMol. Available pack sizes: 2mg, 25mg, 100mg, 250mg, 1g, 5g, on request, 5mg.
LY-2157299 is a pyrrolopyrazole that is 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole which is substituted at positions 2 and 3 by 6-methylpyridin-2-yl and 6-(aminocarbonyl)quinolin-4-yl groups, respectively. A Transforming growth factor-betaRI (TGF-betaRI) kinase inhibitor, it blocks TGF-beta-mediated tumor growth in glioblastoma. It has a role as an antineoplastic agent and a TGFbeta receptor antagonist. It is a member of methylpyridines, a member of quinolines, a monocarboxylic acid amide, a pyrrolopyrazole and an aromatic amide.
Source: ChEBI
| Molecular formula | C22H19N5O |
|---|---|
| Molecular weight | 369.4 g/mol |
| IUPAC name | 4-[2-(6-methyl-2-pyridinyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide |
| InChIKey | IVRXNBXKWIJUQB-UHFFFAOYSA-N |
| SMILES | CC1=NC(=CC=C1)C2=NN3CCCC3=C2C4=C5C=C(C=CC5=NC=C4)C(=O)N |
Computed by PubChem (NCBI)