Products 849773-64-4
CAS 849773-64-4 is the registry number for ARP 101 >= 98 % HPLC, solid. Offered by: Sigma-Aldrich. Available pack sizes: 5MG.
N(2)-([biphenyl]-4-ylsulfonyl)-N-hydroxy-N(2)-isopropoxy-D-valinamide is a hydroxamic acid that is N-hydroxy-D-valinamide in which the alpha-amino group has been substituted by isopropoxy and [biphenyl]-4-ylsulfonyl groups. A selective matrix metalloproteinase-2 (MMP-2) inhibitor, it is one of the most potent inducers of autophagy. Its physiological roles include angiogenesis, cancer metastasis, embryogenesis, tissue remodeling in development, and wound healing. It has a role as an autophagy inducer, an antineoplastic agent, a melanin synthesis inhibitor and an EC 3.4.24.24 (gelatinase A) inhibitor. It is a hydroxamic acid and a D-valine derivative.
Source: ChEBI
| Molecular formula | C20H26N2O5S |
|---|---|
| Molecular weight | 406.5 g/mol |
| IUPAC name | (2R)-N-hydroxy-3-methyl-2-[(4-phenylphenyl)sulfonyl-propan-2-yloxyamino]butanamide |
| InChIKey | DGZZVIWCMGVHGV-LJQANCHMSA-N |
| SMILES | CC(C)[C@H](C(=O)NO)N(OC(C)C)S(=O)(=O)C1=CC=C(C=C1)C2=CC=CC=C2 |
Computed by PubChem (NCBI)
Synonyms:
orb1704900, N(2)-([biphenyl]-4-ylsulfonyl)-N-hydroxy-N(2)-isopropoxy-D-valinamide, (R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-hydroxy-3-methyl-butyramide, N(2)-([biphenyl]-4-ylsulfonyl)-N-hydroxy-N(2)-(propan-2-yloxy)-D-valinamide, N~2~-([1,1'-Biphenyl]-4-sulfonyl)-N-hydroxy-N~2~-[(propan-2-yl)oxy]-D-valinamide