CAS 871700-17-3 appears in our catalog under these names: Trametinib, Trametinib, >95% (HPLC), Trametinib/ 99.88% (existing batch purity), Trametinib (GSK1120212), GSK1120212. Offered by: Chemat Brand, TRC, TargetMol, GLPBio, Chemat. Available pack sizes: on request, 100mg, 10mg, 50mg, 5mg, 200mg, 10mM (in 1ml dmso), 500mg.
Trametinib is a pyridopyrimidine that is used (as its dimethyl sulfoxide addition compound) for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations, and who have not received prior BRAF inhibitor treatment. It has a role as an anticoronaviral agent, a geroprotector, an antineoplastic agent and an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor. It is a member of acetamides, an aromatic amine, a ring assembly, an organoiodine compound, an organofluorine compound, a pyridopyrimidine and a member of cyclopropanes.
Source: ChEBI
| Molecular formula | C26H23FIN5O4 |
|---|---|
| Molecular weight | 615.4 g/mol |
| IUPAC name | N-[3-[3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide |
| InChIKey | LIRYPHYGHXZJBZ-UHFFFAOYSA-N |
| SMILES | CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5 |
Computed by PubChem (NCBI)