CAS 955365-80-7 appears in our catalog under these names: Adavosertib (MK-1775), MK 1775, >95% (HPLC), Adavosertib/ 99.53% (existing batch purity), MK–1775, MK 1775. Offered by: Chemat Brand, TRC, TargetMol, GLPBio, Biosynth. Available pack sizes: on request, 10mg, 50mg, 5mg, 25mg, 100mg, 200mg, 500mg.
Adavosertib is a member of the class of pyrazolopyrimidines that is 1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one substituted by 6-(2-hydroxypropan-2-yl)pyridin-2-yl, prop-1-en-3-yl, [4-(4-methylpiperazin-1-yl)phenyl]amino groups at positions 1, 2, and 6, respectively. It is a potent and selective oral inhibitor of WEE1 kinase. It has a role as an antineoplastic agent and an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor. It is a member of pyridines, a tertiary alcohol, a pyrazolopyrimidine, a N-arylpiperazine, a N-methylpiperazine and a secondary amino compound.
Source: ChEBI
| Molecular formula | C27H32N8O2 |
|---|---|
| Molecular weight | 500.6 g/mol |
| IUPAC name | 1-[6-(2-hydroxypropan-2-yl)-2-pyridinyl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-prop-2-enylpyrazolo[3,4-d]pyrimidin-3-one |
| InChIKey | BKWJAKQVGHWELA-UHFFFAOYSA-N |
| SMILES | CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC=C(C=C4)N5CCN(CC5)C)O |
Computed by PubChem (NCBI)