Products 836620-48-5
CAS 836620-48-5 appears in our catalog under these names: AS1842856/ 99.56% (existing batch purity), AS1842856, AS1842856 99%, Foxo1 Inhibitor, AS1842856 1PC X 10MG, AS1842856, 98%, 98%. Offered by: TargetMol, GLPBio, Biosynth, Ambeed, Sigma-Aldrich. Available pack sizes: 5mg, 10mg, 25mg, 50mg, 100mg, 200mg, 500mg, 1g.
AS1842856 is a quinolone that is 4-quinolone substituted at positions 1, 3, 5, 6 and 7 by ethyl, carboxy, amino, fluorine, and cyclohexylamino groups, respectively. It can directly bind to and block the transcription activity of the active forkhead box protein O1 (Foxo1), but not the Ser256-phosphorylated form. It induces cell death and growth arrest in Burkitt lymphoma cell lines at low concentrations. It has a role as a forkhead box protein O1 inhibitor, a hypoglycemic agent, an antineoplastic agent, an apoptosis inducer, an anti-obesity agent and an autophagy inhibitor. It is a quinolone, a quinolinemonocarboxylic acid, an organofluorine compound, a primary amino compound, a secondary amino compound and a tertiary amino compound.
Source: ChEBI
| Molecular formula | C18H22FN3O3 |
|---|---|
| Molecular weight | 347.4 g/mol |
| IUPAC name | 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxoquinoline-3-carboxylic acid |
| InChIKey | MOMCHYGXXYBDCD-UHFFFAOYSA-N |
| SMILES | CCN1C=C(C(=O)C2=C1C=C(C(=C2N)F)NC3CCCCC3)C(=O)O |
Computed by PubChem (NCBI)