AZD1080, 99.16%
cas: 612487-72-6 — see every product listed under this CAS number, including other names
AZD1080, 99.16% (CAS 612487-72-6) is a chemical reagent available from Chemat. Available pack sizes: 10 mg, 10mM/1mL, 100 mg, 5 mg, 50 mg. Offered by: MedChemExpress.
| brand | MedChemExpress |
|---|---|
| catalog number | HY-13862-10 mg |
| cas | 612487-72-6 |
| size | 10 mg |
| availability | In stock |
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Available pack sizes
| brand | size | price | |
|---|---|---|---|
| MedChemExpress | 10 mg | 909.48 Pln | |
| MedChemExpress | 10mM/1mL | 468.30 Pln | |
| MedChemExpress | 100 mg | 4076.69 Pln | |
| MedChemExpress | 5 mg | 593.69 Pln | |
| MedChemExpress | 50 mg | 2493.08 Pln |
properties
| delivery time | 1-2 weeks |
|---|---|
| purity | 99.16% |
AZD1080 is a member of the class of hydroxyindoles that is 1H-indole substituted by hydroxy, 5-(morpholin-4-ylmethyl)pyridin-2-yl, and cyano groups at positions 2, 3 and 5, respectively. It is a potent, brain permeable inhibitor of human GSK3alpha and GSK3beta with Ki of 6.9 nM and 31 nM, respectively. The drug was being developed by AstraZeneca for the treatment of Alzheimer's disease (clinical trial now discontinued). It has a role as a tau aggregation inhibitor, an antineoplastic agent, an apoptosis inducer and an EC 2.7.11.26 (tau-protein kinase) inhibitor. It is a nitrile, a member of pyridines, a member of morpholines, a tertiary amino compound and a member of hydroxyindoles.
Source: ChEBI
| Molecular formula | C19H18N4O2 |
|---|---|
| Molecular weight | 334.4 g/mol |
| IUPAC name | 2-hydroxy-3-[5-(morpholin-4-ylmethyl)-2-pyridinyl]-1H-indole-5-carbonitrile |
| InChIKey | BLTVBQXJFVRPFK-UHFFFAOYSA-N |
| SMILES | C1COCCN1CC2=CN=C(C=C2)C3=C(NC4=C3C=C(C=C4)C#N)O |
Computed by PubChem (NCBI)
Synonyms:
2-Hydroxy-3-(5-((morpholin-4-yl)methyl)pyridin-2-yl)-1H-indole-5-carbonitrile, 1H-Indole-5-carbonitrile, 2-hydroxy-3-(5-(4-morpholinylmethyl)-2-pyridinyl)-, 2-Hydroxy-3-[5-[(morpholin-4-yl)methyl]pyridin-2-yl]-1H-indole-5-carbonitrile, 2-hydroxy-3-(5-(morpholinomethyl)pyridin-2-yl)-1H-indole-5-carbonitrile, 2-Hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]-1H-indole-5-carbonitrile, 2-Hydroxy-3-[5-(4-morpholinylmethyl)-2-pyridinyl]-1H-indole-5-carbonitrile, Kinome_2945, orb1224464, orb1307560, BLTVBQXJFVRPFK-UHFFFAOYSA-N