AZD1080
cas: 612487-72-6 — see every product listed under this CAS number, including other names
AZD1080 (CAS 612487-72-6) is a chemical reagent available from Chemat. Available pack sizes: on request, 100mg, 10mg, 25mg, 5mg, 10mM (in 1ml dmso), 50mg. Offered by: Chemat Brand, TRC, GLPBio, Biosynth.
| brand | Chemat Brand |
|---|---|
| catalog number | ULA308001 |
| cas | 612487-72-6 |
| size | on request |
| availability | Do potwierdzenia przez Chemat|To be confirmed by Chemat |
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Available pack sizes
| brand | size | price | |
|---|---|---|---|
| Chemat Brand | on request | price on request | |
| TRC | 100mg | price on request | |
| GLPBio | 10mg | 1046.37 Pln | |
| GLPBio | 100mg | 3573.84 Pln | |
| GLPBio | 25mg | 1701.64 Pln | |
| GLPBio | 5mg | 793.62 Pln | |
| GLPBio | 10mM (in 1ml dmso) | 901.27 Pln | |
| GLPBio | 50mg | 2310.10 Pln | |
| Biosynth | 50mg | price on request | |
| Biosynth | 25mg | price on request | |
| Biosynth | 100mg | price on request |
properties
| purity | No data |
|---|---|
| category | Chemicals |
| delivery time | To be confirmed by Chemat |
AZD1080 is a member of the class of hydroxyindoles that is 1H-indole substituted by hydroxy, 5-(morpholin-4-ylmethyl)pyridin-2-yl, and cyano groups at positions 2, 3 and 5, respectively. It is a potent, brain permeable inhibitor of human GSK3alpha and GSK3beta with Ki of 6.9 nM and 31 nM, respectively. The drug was being developed by AstraZeneca for the treatment of Alzheimer's disease (clinical trial now discontinued). It has a role as a tau aggregation inhibitor, an antineoplastic agent, an apoptosis inducer and an EC 2.7.11.26 (tau-protein kinase) inhibitor. It is a nitrile, a member of pyridines, a member of morpholines, a tertiary amino compound and a member of hydroxyindoles.
Source: ChEBI
| Molecular formula | C19H18N4O2 |
|---|---|
| Molecular weight | 334.4 g/mol |
| IUPAC name | 2-hydroxy-3-[5-(morpholin-4-ylmethyl)-2-pyridinyl]-1H-indole-5-carbonitrile |
| InChIKey | BLTVBQXJFVRPFK-UHFFFAOYSA-N |
| SMILES | C1COCCN1CC2=CN=C(C=C2)C3=C(NC4=C3C=C(C=C4)C#N)O |
Computed by PubChem (NCBI)
Synonyms:
2-Hydroxy-3-(5-((morpholin-4-yl)methyl)pyridin-2-yl)-1H-indole-5-carbonitrile, 1H-Indole-5-carbonitrile, 2-hydroxy-3-(5-(4-morpholinylmethyl)-2-pyridinyl)-, 2-Hydroxy-3-[5-[(morpholin-4-yl)methyl]pyridin-2-yl]-1H-indole-5-carbonitrile, 2-hydroxy-3-(5-(morpholinomethyl)pyridin-2-yl)-1H-indole-5-carbonitrile, 2-Hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]-1H-indole-5-carbonitrile, 2-Hydroxy-3-[5-(4-morpholinylmethyl)-2-pyridinyl]-1H-indole-5-carbonitrile, Kinome_2945, orb1224464, orb1307560, BLTVBQXJFVRPFK-UHFFFAOYSA-N