Afatinib

cas: 850140-72-6 — see every product listed under this CAS number, including other names

Afatinib (CAS 850140-72-6) is a chemical reagent available from Chemat. Available pack sizes: 2g, 1g, 5g, 25g, 10g. Offered by: Biosynth.

brandBiosynth
catalog numberFC17230-2g
cas850140-72-6
size2g
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properties

categoryResearch Chemicals
purityNo data
delivery time1-2 weeks
Structural formula: {0} (CAS {1})

Afatinib is a quinazoline compound having a 3-chloro-4-fluoroanilino group at the 4-position, a 4-dimethylamino-trans-but-2-enamido group at the 6-position, and an (S)-tetrahydrofuran-3-yloxy group at the 7-position. Used (as its dimaleate salt) for the first-line treatment of patients with metastatic non-small cell lung cancer. It has a role as an antineoplastic agent and a tyrosine kinase inhibitor. It is a secondary carboxamide, a member of furans, an aromatic ether, an organofluorine compound, a member of quinazolines, a tertiary amino compound, an enamide and a member of monochlorobenzenes.

Source: ChEBI

Identity
Molecular formulaC24H25ClFN5O3
Molecular weight485.9 g/mol
IUPAC name(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
InChIKeyULXXDDBFHOBEHA-CWDCEQMOSA-N
SMILESCN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4

Computed by PubChem (NCBI)

Synonyms: Afatinib, Tomtovok, afatinibum, Tovok, (E/Z)-Afatinib, Afatinib (BIBW2992), Afatinib free base, Afatinib, Free Base, C24H25ClFN5O3, Afatinib [USAN:INN]
Related forms of this compound
(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3R)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide C24H25ClFN5O3
(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide C24H25ClFN5O3
(Z)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide C24H25ClFN5O3
(E)-4-[bis(trideuteriomethyl)amino]-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]but-2-enamide C24H25ClFN5O3
(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3R)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide C24H25ClFN5O3
Isomers (same molecular formula)
N-[4-(3-chloro-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide C24H25ClFN5O3
(E)-N-[4-(4-chloro-3-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide C24H25ClFN5O3

Also listed as

Afatinib (BIBW 2992) Chemat Brand CAS 850140-72-6
Afatinib, >95% (HPLC) TRC CAS 850140-72-6
Afatinib/ 99.9% TargetMol CAS 850140-72-6
Afatinib - Bio-X â„¢ Biosynth CAS 850140-72-6
Afatinib, >97.0%(HPLC)(N) TCI CAS 850140-72-6
Afatinib, 96% Thermo Scientific (Acros) CAS 850140-72-6
Afatinib, 1 g Roth CAS 850140-72-6
Afatinib, 2 g Roth CAS 850140-72-6
Afatinib, min. 95 %, BioScience Grade, 10 mg Roth CAS 850140-72-6
Afatinib, 99.93% MedChemExpress CAS 850140-72-6
Afatinib (Standard), 97.64% MedChemExpress CAS 850140-72-6
Afatinib, Free Base, 99% Fluorochem CAS 850140-72-6
Afatinib, 99% Ambeed CAS 850140-72-6