CAS 123318-82-1 appears in our catalog under these names: Clofarabine, Clofarabine, >95% (HPLC), Clofarabine/ 100%, 2-Chloro-2'-arabino-fluoro-2'- , Clofarabine, >98.0%(HPLC). Offered by: Chemat Brand, TRC, Mikromol, TargetMol, GLPBio. Available pack sizes: on request, 100mg, 10mg, 5mg, 250mg, 25mg, 50mg, 200mg.
Clofarabine is a purine nucleoside analogue consisting of a 6-amino-2-chloropurin-9-yl group attached to the 1beta position of 2'-deoxy-2'-fluoro-D-arabinofuranose. It is metabolized intracellularly to the active 5'-triphosphate metabolite, which inhibits DNA synthesisis and so stops the growth of cancer cells. Clofarabine is used as an antimetabolite antineoplastic agent in the treatment of relapsed or refractory acute lymphoblastic leukaemia. It has a role as an antimetabolite and an antineoplastic agent. It is a member of adenosines and an organofluorine compound.
Source: ChEBI
| Molecular formula | C10H11ClFN5O3 |
|---|---|
| Molecular weight | 303.68 g/mol |
| IUPAC name | (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol |
| InChIKey | WDDPHFBMKLOVOX-AYQXTPAHSA-N |
| SMILES | C1=NC2=C(N=C(N=C2N1[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)F)Cl)N |
Computed by PubChem (NCBI)