Products 103745-39-7
CAS 103745-39-7 appears in our catalog under these names: Fasudil dihydrochloride, 95%, Fasudil, Fasudil/ 99.84% (existing batch purity), Fasudil, 98+% , Fasudil 95%. Offered by: Combi-blocks, TRC, TargetMol, GLPBio, Thermo Scientific (Alfa Aesar). Available pack sizes: 250mg, 5g, 1g, 100mg, 50mg, 200mg, 500mg, 10mg.
Fasudil is an isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia. It has a role as a geroprotector, a vasodilator agent, an antihypertensive agent, a calcium channel blocker, an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor, a neuroprotective agent and a nootropic agent. It is a member of isoquinolines and a N-sulfonyldiazepane. It is a conjugate base of a fasudil(1+).
Source: ChEBI
| Molecular formula | C14H17N3O2S |
|---|---|
| Molecular weight | 291.37 g/mol |
| IUPAC name | 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline |
| InChIKey | NGOGFTYYXHNFQH-UHFFFAOYSA-N |
| SMILES | C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3 |
Computed by PubChem (NCBI)
Synonyms:
Fasudil, ha-1077, Fasudilum, 1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)-, 1-(5-Isoquinolinesulfonyl)homopiperazine, Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine, 5-[(Hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]isoquinoline, 5-(1,4-diazepane-1-sulfonyl)isoquinoline, 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline, Fasudil [INN]