Products 1356962-20-3
CAS 1356962-20-3 appears in our catalog under these names: AZD3463, AZD–3463, AZD-3463/ 99.13% (existing batch purity), AZD-3463 99%, N-(4-(4-Aminopiperidin-1-yl)-2-methoxyphenyl)-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine, 99%, 99%. Offered by: TRC, GLPBio, TargetMol, Biosynth, Ambeed. Available pack sizes: 100mg, 10mg, 5mg, 10mM (in 1ml dmso), 50mg, 25mg, 250mg, 10mM/1mL.
AZD3463 is a member of the class of indoles that is 1H-indole substituted by a 2-[4-(4-aminopiperidin-1-yl)-2-methoxyanilino]-5-chloropyrimidin-4-yl group at position 3. It is an orally bioavailable dual inhibitor of ALK and IGF1R with Ki value of 0.75 nM for ALK. It has a role as an autophagy inducer, an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an apoptosis inducer. It is a member of indoles, a monomethoxybenzene, an organochlorine compound, an aminopyrimidine, an aminopiperidine, a secondary amino compound and a tertiary amino compound.
Source: ChEBI
| Molecular formula | C24H25ClN6O |
|---|---|
| Molecular weight | 448.9 g/mol |
| IUPAC name | N-[4-(4-aminopiperidin-1-yl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine |
| InChIKey | GCYIGMXOIWJGBU-UHFFFAOYSA-N |
| SMILES | COC1=C(C=CC(=C1)N2CCC(CC2)N)NC3=NC=C(C(=N3)C4=CNC5=CC=CC=C54)Cl |
Computed by PubChem (NCBI)