Products 1392502-82-7
CAS 1392502-82-7 is the registry number for Mefuparib, 99.77%. Offered by: MedChemExpress. Available pack sizes: 100 mg, 5 mg, 25 mg, 10 mg, 50 mg.
Mefuparib is a member of the class of 1-benzofurans that is 1-benzofuran substituted by 4-[(methylamino)methyl]phenyl, fluoro and aminocarbonyl groups at positions 2, 5, and 7, respectively. It is a potent inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 (IC50 of 3.2 nM and 1.9 nM, respectively). The compound exhibits anti-cancer properties and has also shown promising antiviral activity against the virus that causes COVID-19. It has a role as an anticoronaviral agent, an antineoplastic agent, an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor and an apoptosis inducer. It is a primary carboxamide, an organofluorine compound, a member of 1-benzofurans and a secondary amino compound. It is a conjugate base of a mefuparib(1+).
Source: ChEBI
| Molecular formula | C17H15FN2O2 |
|---|---|
| Molecular weight | 298.31 g/mol |
| IUPAC name | 5-fluoro-2-[4-(methylaminomethyl)phenyl]-1-benzofuran-7-carboxamide |
| InChIKey | ROBJKLPZIPNAMV-UHFFFAOYSA-N |
| SMILES | CNCC1=CC=C(C=C1)C2=CC3=CC(=CC(=C3O2)C(=O)N)F |
Computed by PubChem (NCBI)
Synonyms:
Mefuparib, MEFUPARIB [WHO-DD], 5-Fluoro-2-(4-((methylamino)methyl)phenyl)-7-benzofurancarboxamide, 5-fluoro-2-{4-[(methylamino)methyl]phenyl}-1-benzofuran-7-carboxamide, 5-Fluoro-2-[4-[(methylamino)methyl]phenyl]-7-benzofurancarboxamide, 5-fluoro-2-(4-((methylamino)methyl)phenyl)-1-benzofuran-7-carboxamide, Mefuparib Free Base, ROBJKLPZIPNAMV-UHFFFAOYSA-N, 5-fluoro-2-{4-[(methylamino)methyl]phenyl}-benzofuran-7-carboxamide, 5-fluoro-2-{4-[(methylamino)methyl]phenyl}benzofuran-7-carboxamide